2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER
• CAS No.: 18418-08-1
• Molecular Formula: C6H8O3
• Molecular Weight: 128.128
• Hs Code.: 2918199090
• Mol file: 18418-08-1.mol

Synonyms:ETHYL 2-HYDROXY-3-BUTYNOATE;2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER;Hydroxybutynoicacidethylester;2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER 95+%

Chemical Property of 2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER

Chemical Property:

• Refractive Index: 1.4420-1.4480
• Boiling Point: 78 °C / 11mmHg
• PSA: 46.53000
• Density: 1.10
• LogP: -0.45640
• Storage Temp.: Freezer

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-Hydroxy-3-butynoate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER

There total 3 articles about 2-HYDROXY-3-BUTYNOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + acetylene (74-86-2,25067-58-7) → ethyl 2-hydroxybut-3-ynoate (18418-08-1)

Guidance literature:

acetylene; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

glyoxylic acid ethyl ester; In tetrahydrofuran; at -40 ℃; for 2h; Inert atmosphere;

DOI:10.1007/s11164-012-0595-9

Reference yield:

ethanol (64-17-5) + 2-Hydroxy-3-butin-nitril (73414-55-8) → ethyl 2-hydroxybut-3-ynoate (18418-08-1)

Guidance literature:

With hydrogenchloride;

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + acetylenemagnesium bromide (4301-14-8) → ethyl 2-hydroxybut-3-ynoate (18418-08-1)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

ethanol

2-Hydroxy-3-butin-nitril

glyoxylic acid ethyl ester

acetylenemagnesium bromide