5-iodo-2-isopropoxybenzonitrile

Base Information

• Chemical Name: 5-iodo-2-isopropoxybenzonitrile
• CAS No.: 1258440-83-3
• Molecular Formula: C₁₀H₁₀INO
• Molecular Weight: 287.1
• Mol file: 1258440-83-3.mol

Synonyms:5-iodo-2-isopropoxybenzonitrile

Chemical Property of 5-iodo-2-isopropoxybenzonitrile

Chemical Property:

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-iodo-2-isopropoxybenzonitrile

There total 4 articles about 5-iodo-2-isopropoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

2-hydroxy-5-iodobenzonitrile (685103-95-1) + 2-iodo-propane (75-30-9) → 5-iodo-2-isopropoxy-benzonitrile (1258440-83-3)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

Reference yield: 84.0%

5-bromo-2-[(1-methylethyl)oxy]benzonitrile (515832-52-7) → 5-iodo-2-isopropoxy-benzonitrile (1258440-83-3)

Guidance literature:

With copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.08.047

Reference yield:

salicylonitrile (611-20-1) → 5-iodo-2-isopropoxy-benzonitrile (1258440-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid; N-iodo-succinimide / acetonitrile / 0 - 20 °C

2: potassium carbonate / acetonitrile / Reflux

With N-iodo-succinimide; trifluorormethanesulfonic acid; potassium carbonate; In acetonitrile;

upstream raw materials:

2-hydroxy-5-iodobenzonitrile

2-iodo-propane

salicylonitrile

5-bromo-2-hydroxybenzonitrile

Downstream raw materials:

2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

2-isopropoxy-5-(5-(5-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,3,4-thiadiazol-2-yl)benzonitrile trifluoroacetate

3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3,4-dihydro-2(1H)-isoquinolinyl]propanamide

3-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3,4-dihydro-2(1H)-isoquinolinyl]-N,N-dimethylpropanamide