3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

Base Information

Chemical Name:3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol
CAS No.:892414-46-9
Molecular Formula:C₈H₇F₃N₂O
Molecular Weight:204.152
Hs Code.:2933998090
DSSTox Substance ID:DTXSID901182733
Mol file:892414-46-9.mol

Synonyms:892414-46-9;3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol;1H-Pyrrolo[2,3-b]pyridin-3-ol, 2,3-dihydro-3-(trifluoromethyl)-;SCHEMBL12131808;DTXSID901182733;CS-M2166;AKOS037650307;CS-14614;C12579;EN300-814129;3-(trifluoromethyl)-1H,2H,3H-pyrrolo[2,3-b]pyridin-3-ol;3-(trifluoromethyl)-1,2-dihydropyrrolo[2,3-b]pyridin-3-ol;2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol

Suppliers and Price of 3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol
2mg
$ 65.00

ChemScene
1H-Pyrrolo[2,3-b]pyridin-3-ol,2,3-dihydro-3-(trifluoromethyl)-
100mg
$ 650.00

Total 7 raw suppliers

Chemical Property of 3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

Chemical Property:

PSA：45.15000
LogP:1.39500
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:0
Exact Mass:204.05104734
Heavy Atom Count:14
Complexity:233

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C2=C(N1)N=CC=C2)(C(F)(F)F)O

Technology Process of 3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

There total 3 articles about 3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 892414-45-8
1,1,1-trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol

: 892414-46-9
3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

Guidance literature:: With hydrogen; nickel; In ethanol; at 20 ℃;
DOI:10.1055/s-2006-958935

Reference yield:

: 372-48-5
2-fluoropyridine

: 892414-46-9
3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -75 °C

1.2: tetrahydrofuran

2.1: 290 g / potassium carbonate / tetrahydrofuran / 20 °C

3.1: 81 percent / H₂ / Raney-nickel / ethanol / 20 °C

With hydrogen; lithium diisopropyl amide; nickel; potassium carbonate; In tetrahydrofuran; ethanol; 2.1: Henry reaction;
DOI:10.1055/s-2006-958935

Reference yield:

: 932406-33-2
2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethane-1,1-diol

: 892414-46-9
3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 290 g / potassium carbonate / tetrahydrofuran / 20 °C

2: 81 percent / H₂ / Raney-nickel / ethanol / 20 °C

With hydrogen; nickel; potassium carbonate; In tetrahydrofuran; ethanol; 1: Henry reaction;
DOI:10.1055/s-2006-958935