(R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate
CAS No.:1224096-01-8
Molecular Formula:C16H22F3N3O3
Molecular Weight:361.364
Hs Code.:
Mol file:1224096-01-8.mol

Synonyms:(R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate

Suppliers and Price of (R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:: 99.99%HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate

There total 3 articles about (R)-tert-butyl 3-(2,6-diaMino-4-(trifluoroMethyl)phenoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1224096-00-7
(R)-3-(2,6-dinitro-4-trifluoromethylphenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1224096-01-8,1159826-37-5
(R)-3-(2,6-diamino-4-trifluoromethylphenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; under 2068.65 Torr; Product distribution / selectivity;

Reference yield:

: 109431-87-0,83220-73-9
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

: 1224096-01-8,1159826-37-5
(R)-3-(2,6-diamino-4-trifluoromethylphenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran; tert-butyl methyl ether / 16 h / 10 - 17 °C / Large scale

2: hydrogen; 5%-palladium/activated carbon / methanol / 98 h / 517.16 - 775.74 Torr / Large scale

With 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; methanol; tert-butyl methyl ether;

Reference yield:

: 393-75-9
4-chloro-3,5-dinitrobenzotrifluoride

: 1224096-01-8,1159826-37-5
(R)-3-(2,6-diamino-4-trifluoromethylphenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran; tert-butyl methyl ether / 16 h / 10 - 17 °C / Large scale

2: hydrogen; 5%-palladium/activated carbon / methanol / 98 h / 517.16 - 775.74 Torr / Large scale

With 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; methanol; tert-butyl methyl ether;