pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

Base Information

Chemical Name:pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}
CAS No.:1224096-02-9
Molecular Formula:C₃₈H₄₄F₆N₈O₈
Molecular Weight:854.807
Hs Code.:

Synonyms:pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

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Chemical Property of pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

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Technology Process of pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

There total 4 articles about pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.1%

: 16490-02-1
pyrimidine-4,6-dicarboxylic acid

: 1224096-01-8,1159826-37-5
(R)-3-(2,6-diamino-4-trifluoromethylphenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1224096-02-9
pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

Guidance literature:: With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; at 20 ℃; for 24.5h; Product distribution / selectivity;

Reference yield:

: 393-75-9
4-chloro-3,5-dinitrobenzotrifluoride

: 1224096-02-9
pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran; tert-butyl methyl ether / 16 h / 10 - 17 °C / Large scale

2: hydrogen; 5%-palladium/activated carbon / methanol / 98 h / 517.16 - 775.74 Torr / Large scale

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 25 h / 20 °C / Inert atmosphere; Large scale

With pyridine; 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; tert-butyl methyl ether;

Reference yield:

: 1224096-00-7
(R)-3-(2,6-dinitro-4-trifluoromethylphenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1224096-02-9
pyrimidine-4,6-dicarboxylic acid bis-{[3-amino-2-((R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)-5-trifluoromethyl-phenyl]amide}

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / methanol / 98 h / 517.16 - 775.74 Torr / Large scale

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 25 h / 20 °C / Inert atmosphere; Large scale

With pyridine; 5%-palladium/activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol;