(4-(4-methylthiazol-5-yl)phenyl)methanamine

Base Information

• Chemical Name: (4-(4-methylthiazol-5-yl)phenyl)methanamine
• CAS No.: 1448189-30-7
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.296
• Mol file: 1448189-30-7.mol

Synonyms:(4-(4-methylthiazol-5-yl)phenyl)methanamine

Chemical Property of (4-(4-methylthiazol-5-yl)phenyl)methanamine

Chemical Property:

• Boiling Point: 343.0±30.0 °C(Predicted)
• PKA: 9.12±0.10(Predicted)
• PSA: 67.15000
• Density: 1.176±0.06 g/cm3(Predicted)
• LogP: 3.27750
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

4-(4-Methylthiazol-5-yl)benzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(4-methylthiazol-5-yl)phenyl)methanamine

There total 10 articles about (4-(4-methylthiazol-5-yl)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(4-methyl-1,3-thiazol-5-yl)benzonitrile (122957-57-7) → 1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methaneamine (1448189-30-7)

Guidance literature:

With diisobutylaluminum borohydride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.0c03062

Reference yield: 89.0%

2-(trimethylsilyl)ethyl 4-(4-methylthiazol-5-yl)benzylcarbamate (1448189-29-4) → 1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methaneamine (1448189-30-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1002/anie.201206231

Reference yield: 73.0%

4-Methylthiazole (693-95-8) + 4-bromobenzenecarbonitrile (623-00-7) → 1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methaneamine (1448189-30-7)

Guidance literature:

4-Methylthiazole; 4-bromobenzenecarbonitrile; With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 150 ℃; for 19h; Inert atmosphere;

With methanol; sodium tetrahydroborate; cobalt(II) chloride; at 4 ℃; for 1.5h;

upstream raw materials:

2-(trimethylsilyl)ethyl 4-bromobenzylcarbamate

2-(trimethylsilyl)ethyl 4-(4-methylthiazol-5-yl)benzylcarbamate

4-bromobenzenecarbonitrile

4-(4-methyl-1,3-thiazol-5-yl)benzonitrile

Downstream raw materials:

tert‐butyl (2S,4R)‐4‐hydroxy‐2‐({[4‐(4‐methyl‐1,3‐thiazol‐5‐yl)phenyl]methyl}carbamoyl)pyrrolidine‐1‐carboxylate

(2S,4R)-4-(tert-butoxy)-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

C₂₅H₂₇N₃O₄S