4-(4-methylthiazol-5-yl) benzonitrile

Base Information

• Chemical Name: 4-(4-methylthiazol-5-yl) benzonitrile
• CAS No.: 122957-57-7
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.264
• Mol file: 122957-57-7.mol

Synonyms:4-(4-methyl-1,3-thiazol-5-yl)benzonitrile

Chemical Property of 4-(4-methylthiazol-5-yl) benzonitrile

Chemical Property:

Purity/Quality:

98+% ^*data from raw suppliers

4-(4-Methylthiazol-5-yl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methylthiazol-5-yl) benzonitrile

There total 3 articles about 4-(4-methylthiazol-5-yl) benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Methylthiazole (693-95-8) + 4-bromobenzenecarbonitrile (623-00-7) → 4-(4-methyl-1,3-thiazol-5-yl)benzonitrile (122957-57-7)

Guidance literature:

With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 150 ℃; for 19h; Inert atmosphere;

DOI:10.1002/anie.201206231

Reference yield: 88.0%

4-Methylthiazole (693-95-8) + 4-iodobenzonitrile (3058-39-7) → 4-(4-methyl-1,3-thiazol-5-yl)benzonitrile (122957-57-7)

Guidance literature:

With palladium(II) trimethylacetate; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol4027073

Reference yield: 79.0%

4-Methylthiazole (693-95-8) + 4-Cyanochlorobenzene (623-03-0) → 4-(4-methyl-1,3-thiazol-5-yl)benzonitrile (122957-57-7)

Guidance literature:

With C₂₃H₂₀ClFeN₃Pd; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 140 ℃; for 10h; Reagent/catalyst; regioselective reaction;

DOI:10.1039/c9dt03465j

upstream raw materials:

4-Methylthiazole

4-bromobenzenecarbonitrile

4-iodobenzonitrile

4-Cyanochlorobenzene

Downstream raw materials:

(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-4-(tert-butoxy)-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methaneamine

C₂₄H₂₂N₄O₃S