Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate

Base Information

Chemical Name:Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate
CAS No.:181283-33-0
Molecular Formula:C₁₀H₈ClNO₂S
Molecular Weight:241.698
Hs Code.:2934999090
DSSTox Substance ID:DTXSID001207570
Mol file:181283-33-0.mol

Synonyms:Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate;181283-33-0;METHYL 3-AMINO-7-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLATE;SCHEMBL8139114;KNJZZJLVDYDEGL-UHFFFAOYSA-N;DTXSID001207570;MFCD25960235;CS-0448622;3-Amino-2-carbomethoxy-7-chloro-benzthiophene;Methyl3-amino-7-chlorobenzo[b]thiophene-2-carboxylate

Suppliers and Price of Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl3-amino-7-chlorobenzo[b]thiophene-2-carboxylate 95+%
1g
$ 491.00

Chemenu
methyl3-amino-7-chlorobenzo[b]thiophene-2-carboxylate 95%
1g
$ 464.00

Alichem
Methyl3-amino-7-chlorobenzo[b]thiophene-2-carboxylate
1g
$ 429.07

Total 8 raw suppliers

Chemical Property of Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate

Chemical Property:

PSA：80.56000
LogP:3.50470
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:240.9964274
Heavy Atom Count:15
Complexity:264

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-amino-7-chlorobenzo[b]thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(C2=C(S1)C(=CC=C2)Cl)N

Technology Process of Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate

There total 6 articles about Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: C₁₀H₆BrClO₂S

: 181283-33-0
3-amino-2-carbomethoxy-7-chloro-benzothiophene

Guidance literature:: With copper(l) iodide; 2-carboxyquinoline N-oxide; ammonia; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 12.0%

: 6574-97-6
2,3-dichlorobenzonitrile

: 2365-48-2
Methyl thioglycolate

: 181283-33-0
3-amino-2-carbomethoxy-7-chloro-benzothiophene

Guidance literature:: With sodium carbonate; In methanol; for 3h; Heating;
DOI:10.1021/jm990567u

Reference yield:

: 50-45-3
2,3-dichlorbenzoic acid

: 181283-33-0
3-amino-2-carbomethoxy-7-chloro-benzothiophene

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / toluene / 4 h / Heating

2: NH₄OH / ethyl acetate

3: POCl₃ / 2 h / 95 °C

4: 12 percent / Na₂CO₃ / methanol / 3 h / Heating

With ammonium hydroxide; oxalyl dichloride; sodium carbonate; trichlorophosphate; In methanol; ethyl acetate; toluene; 1: Chlorination / 2: Amidation / 3: Dehydration / 4: Condensation;
DOI:10.1021/jm990567u