N-[4-(2-hydroxyethyl)phenyl]acetamide

Base Information

• Chemical Name: N-[4-(2-hydroxyethyl)phenyl]acetamide
• CAS No.: 83345-11-3
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID30391170
• Nikkaji Number: J1.747.514B
• Mol file: 83345-11-3.mol

Synonyms:N-[4-(2-hydroxyethyl)phenyl]acetamide;83345-11-3;N-(4-(2-Hydroxyethyl)phenyl)acetamide;CHEMBRDG-BB 5529572;SCHEMBL6629816;4'-(2-Hydroxyethyl)acetanilide;4'-(2-Hydroxyethyl)acetoanilide;DTXSID30391170;MFCD01536093;AKOS005264744;SB85130;BS-50000;CS-0258377;EN300-69921;Z785801482

Chemical Property of N-[4-(2-hydroxyethyl)phenyl]acetamide

Chemical Property:

• Vapor Pressure: 5.71E-07mmHg at 25°C
• Boiling Point: 395.6°C at 760 mmHg
• Flash Point: 193.1°C
• PSA: 49.33000
• Density: 1.172g/cm³
• LogP: 1.25280
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

98% ^*data from raw suppliers

N-[4-(2-hydroxyethyl)phenyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)CCO

Technology Process of N-[4-(2-hydroxyethyl)phenyl]acetamide

There total 5 articles about N-[4-(2-hydroxyethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-Acetamidophenyl)ethyl acetate (75178-16-4) → N-[4-(2-hydroxylethyl)phenyl]acetamide (83345-11-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 3h;

Reference yield: 96.0%

1-[4-(2-hydroxyethyl)phenyl]ethanone oxime (102494-22-4) → N-[4-(2-hydroxylethyl)phenyl]acetamide (83345-11-3)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; perfluoropinacol; 2-(phenoxycarbonyl)phenylboronic acid; In nitromethane; at 20 ℃; for 24h; chemoselective reaction;

DOI:10.1021/jacs.8b01618

Reference yield: 39.2%

acetic anhydride (108-24-7) + 2-(4'-aminophenyl)ethyl alcohol (104-10-9) → N-[4-(2-hydroxylethyl)phenyl]acetamide (83345-11-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

upstream raw materials:

acetic anhydride

2-(4'-aminophenyl)ethyl alcohol

2-(4-Acetamidophenyl)ethyl acetate

1-[4-(2-hydroxyethyl)phenyl]ethanone oxime

Downstream raw materials:

(p-acetylamino)phenylacetaldehyde

6-[[2-(4-acetylaminophenyl)ethoxy](4-nitrophenoxy)phosphoryl]hexanoic acid 2-(toluene-4-sulfonyl)ethyl ester

propionic acid 2-(4-acetylaminophenyl)ethyl ester

toluene-4-sulfonic acid 2-(4-acethylaminophenyl)ethyl ester