(2-BroMo-5-thiazolyl)-1-piperidinylMethanone

Base Information

• Chemical Name: (2-BroMo-5-thiazolyl)-1-piperidinylMethanone
• CAS No.: 1290136-85-4
• Molecular Formula: C9H11BrN2OS
• Molecular Weight: 275.169
• Hs Code.: 2934100090
• Mol file: 1290136-85-4.mol

Synonyms:(2-BroMo-5-thiazolyl)-1-piperidinylMethanone;(2-Bromothiazol-5-yl)(piperidin-1-yl)methanone

Chemical Property of (2-BroMo-5-thiazolyl)-1-piperidinylMethanone

Chemical Property:

• PSA: 61.44000
• LogP: 2.46960
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

(2-bromothiazol-5-yl)(piperidin-1-yl)methanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-BroMo-5-thiazolyl)-1-piperidinylMethanone

There total 1 articles about (2-BroMo-5-thiazolyl)-1-piperidinylMethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

piperidine (110-89-4) + 2-bromo-thiazole-5-carboxylic acid (54045-76-0) → (2-bromo-thiazol-5-yl)-piperidin-1-yl-methanone (1290136-85-4)

Guidance literature:

2-bromo-thiazole-5-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

piperidine; In dichloromethane; at 23 ℃; for 4h;

Reference yield:

1-ethynyl-3-methoxybenzene (768-70-7) + (2-bromo-thiazol-5-yl)-piperidin-1-yl-methanone (1290136-85-4) → [2-(3-Methoxy-phenylethynyl)-thiazol-5-yl]-piperidin-1-yl-methanone (1290136-04-7)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

Reference yield:

(2-bromo-thiazol-5-yl)-piperidin-1-yl-methanone (1290136-85-4) → [2-(3-Hydroxy-phenylethynyl)-thiazol-5-yl]-piperidin-1-yl-methanone (1290135-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 100 °C / Microwave irradiation; Inert atmosphere

2: boron tribromide / dichloromethane / 3 h / 23 °C

With boron tribromide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

piperidine

2-bromo-thiazole-5-carboxylic acid

Downstream raw materials:

[2-(3-Methoxy-phenylethynyl)-thiazol-5-yl]-piperidin-1-yl-methanone

[2-(3-Hydroxy-phenylethynyl)-thiazol-5-yl]-piperidin-1-yl-methanone

Refernces