(S)-p-Chlorophenyl-phenylMethanaMine

Base Information

• Chemical Name: (S)-p-Chlorophenyl-phenylMethanaMine
• CAS No.: 163837-32-9
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Hs Code.: 2921499090
• Mol file: 163837-32-9.mol

Synonyms:(S)-p-Chlorophenyl-phenylMethanaMine;(S)-(4-chlorophenyl)(phenyl)MethanaMine;(S)-^a-(4-Chlorophenyl)benzylaMine, 98%

Chemical Property of (S)-p-Chlorophenyl-phenylMethanaMine

Chemical Property:

• Boiling Point: 336.8±27.0 °C(Predicted)
• PKA: 8.08±0.10(Predicted)
• PSA: 26.02000
• Density: 1.175±0.06 g/cm3(Predicted)
• LogP: 4.08840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

(S)-(4-Chlorophenyl)(phenyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-p-Chlorophenyl-phenylMethanaMine

There total 25 articles about (S)-p-Chlorophenyl-phenylMethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+)-(S)-Phenyl N-(4-chlorobenzhydryl)carbamate → (S)-4-chloro-α-phenyl-benzenemethanamine (163837-32-9)

Guidance literature:

With lithium hydroxide; water; In acetonitrile; at 50 ℃; for 3h;

DOI:10.1055/s-2000-6391

Reference yield: 98.0%

(S)-(+)-N-[(4-chlorophenyl)phenylmethyl]-4-nitrobenzenesulfonamide (260997-46-4) → (S)-4-chloro-α-phenyl-benzenemethanamine (163837-32-9)

Guidance literature:

With potassium carbonate; para-thiocresol; In N,N-dimethyl-formamide; at 20 ℃; for 2h; optical yield given as %ee;

DOI:10.1055/s-0030-1258210

Reference yield: 95.0%

(RS,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide (439695-63-3) → (S)-4-chloro-α-phenyl-benzenemethanamine (163837-32-9)

Guidance literature:

With hydrogenchloride; In methanol; at 22 ℃;

DOI:10.1016/S0040-4039(01)02294-8

upstream raw materials:

(S)-(+)-N-[(4-chlorophenyl)phenylmethyl]-4-nitrobenzenesulfonamide

(R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide

(R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide

(S)-N-((4-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Downstream raw materials:

[(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine

(S)-(+)-N-[(4-chlorophenyl)(phenyl)methyl]pivalamide

(-)-1-[(4-chloro-phenyl)-phenyl-methyl]-4-(4-methoxy-benzyl)piperazine

p-chlorobenzophenone imine

Refernces

• 1、 Dawood, Ayad W. H.,Wei?, Martin S.,Schulz, Christian,Pavlidis, Ioannis V.,Iding, Hans,de Souza, Rodrigo O. M. A.,Bornscheuer, Uwe T.. "Isopropylamine as Amine Donor in Transaminase-Catalyzed Reactions: Better Acceptance through Reaction and Enzyme Engineering". . p. 3943 - 3949. Retrieved 2018/07/31.
• 2、 Pavlidis, Ioannis V.,Wei?, Martin S.,Genz, Maika,Spurr, Paul,Hanlon, Steven P.,Wirz, Beat,Iding, Hans,Bornscheuer, Uwe T.. "Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines". . p. 1076 - 1082. Retrieved 2016/11/02.