439695-63-3

Upstream product

• 336105-23-8 (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 100-52-7 benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 591-51-5 phenyllithium 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 246870-46-2 (S)-(-)-cetirizine ethyl ester 
• 163837-58-9 1-[(S)-(4-Chloro-phenyl)-phenyl-methyl]-4-(toluene-4-sulfonyl)-piperazine 
• 439858-21-6 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine 
• 130018-87-0 (+)-Cetirizine dihydrochloride 
• 451503-28-9 (α¹S)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 
• 163837-32-9 (S)-4-chloro-α-phenyl-benzenemethanamine 

Relevant academic research and scientific papers

Diastereoselective and enantioselective Rh(I)-catalyzed additions of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl aldimines

Two new Rh(I)-catalyzed methods for the synthesis of chiral α-branched amines via addition of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl imines have been developed. The syntheses are more functional group tolerant than alternativ

Asymmetric synthesis of cetirizine dihydrochloride

Practical route technology for the preparation of (S)-cetirizine·2HCl via diastereoselective organometallic addition to N-tert-butanesulfinyl aldimines is disclosed.

Asymmetric synthesis of diarylmethylamines by diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines: Switchover of diastereofacial selectivity

Diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines gave alkylated adducts in high yields and diastereoselectivities. Cleavage of the chiral auxiliary under mildly acidic conditions gave diarylmethylamines in high yi