METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-5-CARBOXYLATE

Base Information

• Chemical Name: METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-5-CARBOXYLATE
• CAS No.: 1017273-31-2
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.18
• Hs Code.: 2934999090
• Mol file: 1017273-31-2.mol

Synonyms:METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-5-CARBOXYLATE

Chemical Property of METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-5-CARBOXYLATE

Chemical Property:

• PSA: 68.12000
• LogP: 0.88920

Purity/Quality:

98%min ^*data from raw suppliers

3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-5-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-5-CARBOXYLATE

There total 4 articles about METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

methyl 3-(2-ethoxy-2-oxoethoxy)-2-nitrobenzoate → methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate (1017273-31-2)

Guidance literature:

With iron; In acetic acid; at 90 ℃; for 4h;

Reference yield: 81.0%

2-amino-3-hydroxy-benzoic acid methyl ester (17672-21-8) + chloroacetyl chloride (79-04-9) → methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate (1017273-31-2)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

3-hydroxyanthranilic acid (548-93-6) → methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate (1017273-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / methanol / 2 h / Reflux

2: triethylamine / acetonitrile / 0 - 20 °C

With thionyl chloride; triethylamine; In methanol; acetonitrile;

upstream raw materials:

2-amino-3-hydroxy-benzoic acid methyl ester

chloroacetyl chloride

3-hydroxyanthranilic acid

methyl 3-hydroxy-2-nitrobenzoate

Downstream raw materials:

methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate

methyl 4-(4-chlorobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-5-carboxylate

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