6-Methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol

Base Information

Chemical Name:6-Methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol
CAS No.:165072-41-3
Molecular Formula:C₁₂H₁₆O₂
Molecular Weight:192.258
Hs Code.:
DSSTox Substance ID:DTXSID40434481
Mol file:165072-41-3.mol

Synonyms:165072-41-3;6-methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol;2,3-DIHYDRO-2,2-DIMETHYL-6-METHOXY-1H-INDEN-1-OL;AGN-PC-0MXNJN;DTXSID40434481;AKOS006305918

Suppliers and Price of 6-Methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 6-Methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol

Chemical Property:

PSA：29.46000
LogP:2.31090
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:192.115029749
Heavy Atom Count:14
Complexity:212

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC2=C(C1O)C=C(C=C2)OC)C

Technology Process of 6-Methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol

There total 2 articles about 6-Methoxy-2,2-dimethyl-1,3-dihydroinden-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 124688-07-9
6-methoxy-2,2-dimethyl-1-indanone

: 165072-41-3
6-methoxy-2,2-dimethyl-2,3-dihydro-1H-indene-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/adsc.201900761

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 74-88-4
methyl iodide

: 165072-41-3
6-methoxy-2,2-dimethyl-2,3-dihydro-1H-indene-1-ol

Guidance literature:: 6-methoxy-2,3-dihydro-1H-inden-1-one; With sodium t-butanolate; In tetrahydrofuran; at -10 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -10 - 20 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1055/s-0039-1690109

Reference yield: 47.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 165072-41-3
6-methoxy-2,2-dimethyl-2,3-dihydro-1H-indene-1-ol

: (R)-6-methoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl (tert-butoxycarbonyl)-L-phenylalaninate

: (S)-6-methoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl (tert-butoxycarbonyl)-L-phenylalaninate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 4h; Overall yield = 94%; Overall yield = 2.06g;
DOI:10.1021/jacs.6b01462