4-[(E)-2-(4-methylphenyl)ethenyl]phenol

Base Information

• Chemical Name: 4-[(E)-2-(4-methylphenyl)ethenyl]phenol
• CAS No.: 18951-45-6
• Molecular Formula: C15H14O
• Molecular Weight: 210.276
• Nikkaji Number: J1.662.270B,J303.852A
• Mol file: 18951-45-6.mol

Synonyms:4-[(E)-2-(4-methylphenyl)ethenyl]phenol;4-((E)-2-(4-Methylphenyl)ethenyl)phenol;18951-45-6;4'-Methylstilbene-4-ol;SCHEMBL9571496

Chemical Property of 4-[(E)-2-(4-methylphenyl)ethenyl]phenol

Chemical Property:

• Vapor Pressure: 1.83E-05mmHg at 25°C
• Boiling Point: 352.9°Cat760mmHg
• Flash Point: 168.6°C
• Density: 1.122g/cm³
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 210.104465066
• Heavy Atom Count: 16
• Complexity: 218

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C=CC2=CC=C(C=C2)O
• Isomeric SMILES: CC1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)O

Technology Process of 4-[(E)-2-(4-methylphenyl)ethenyl]phenol

There total 10 articles about 4-[(E)-2-(4-methylphenyl)ethenyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-Iodophenol (540-38-5) + (E)-β-(2-pyridyldimethylsilyl)-4-methylstyrene (321155-43-5) → (E)-1-(4-hydroxy)phenyl-2-(4-methyl)phenylethene (18951-45-6)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/ja016790+

Reference yield: 72.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 4-hydroxybenzenediazonium tetrafluoroborate → (E)-1-(4-hydroxy)phenyl-2-(4-methyl)phenylethene (18951-45-6)

Guidance literature:

With sodium acetate; palladium diacetate; In methanol; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c3ob40420j

Reference yield: 61.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 4-Vinylphenol (2628-17-3,24979-70-2) → (E)-1-(4-hydroxy)phenyl-2-(4-methyl)phenylethene (18951-45-6)

Guidance literature:

4-Vinylphenol; With caesium carbonate; sodium iodide; Merrifield resin; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

1-ethenyl-4-methylbenzene; RuCl₂(=CHPh)[1,3-ImH₂]P(Cy)3; In benzene; at 80 ℃; for 12h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(02)01528-9

upstream raw materials:

(E)-4'-methoxy-4-methylstilbene

p-Iodophenol

(E)-β-(2-pyridyldimethylsilyl)-4-methylstyrene

1-ethenyl-4-methylbenzene

Downstream raw materials:

4-methoxy-N-[(4-methylphenyl)methylidene]aniline

4-(4-hydroxyphenyl)-N-(4-methoxyphenyl)imine

4-methoxy-N-(4-methylbenzyl)aniline

4-(((4-methoxyphenyl)amino)methyl)phenol