4-[(4-Methoxyanilino)methyl]phenol

Base Information

Chemical Name:4-[(4-Methoxyanilino)methyl]phenol
CAS No.:73351-21-0
Molecular Formula:C₁₄H₁₅NO₂
Molecular Weight:229.279
Hs Code.:
European Community (EC) Number:666-206-3

Synonyms:4-[(4-methoxyanilino)methyl]phenol;SCHEMBL5863587;AKOS000241551;73351-21-0;4-(((4-Methoxyphenyl)amino)methyl)phenol

Suppliers and Price of 4-[(4-Methoxyanilino)methyl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(4-Methoxyanilino)methyl]phenol

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:229.110278721
Heavy Atom Count:17
Complexity:206

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)NCC2=CC=C(C=C2)O

Technology Process of 4-[(4-Methoxyanilino)methyl]phenol

There total 33 articles about 4-[(4-Methoxyanilino)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-17-4
para-methoxynitrobenzene

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 73351-21-0
4-(((4-methoxyphenyl)amino)methyl)phenol

Guidance literature:: With carbon monoxide; water; In tetrahydrofuran; at 120 ℃; for 24h; under 3800.26 Torr;
DOI:10.1021/acscatal.5b01198

Reference yield:

: 4-hydroxybenzenediazonium tetrafluoroborate

: 73351-21-0
4-(((4-methoxyphenyl)amino)methyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; palladium diacetate / 12 h / 20 °C / Inert atmosphere

2.1: iron(II) chloride / acetonitrile / 10 h / 100 °C / Sealed tube; Inert atmosphere

2.2: 20 °C

With sodium acetate; palladium diacetate; iron(II) chloride; In acetonitrile;
DOI:10.1021/acs.orglett.9b03160

Reference yield:

: 14064-83-6
trans-4-hydroxy-4'-nitrostilbene

: 2101-87-3
p-methoxy-phenylazide

: 16035-87-3
N-(p-nitrobenzyl)-p-anisidine

: 73351-21-0
4-(((4-methoxyphenyl)amino)methyl)phenol

Guidance literature:: trans-4-hydroxy-4'-nitrostilbene; p-methoxy-phenylazide; With iron(II) chloride; In acetonitrile; at 100 ℃; for 10h; Sealed tube; Inert atmosphere;

With methanol; sodium tetrahydroborate; at 20 ℃;
DOI:10.1021/acs.orglett.9b03160