Acridine, 2-methoxy-

Base Information

• Chemical Name: Acridine, 2-methoxy-
• CAS No.: 3295-60-1
• Molecular Formula: C14H11NO
• Molecular Weight: 209.2432
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80186598
• Nikkaji Number: J55.104J
• Wikidata: Q83057938
• Mol file: 3295-60-1.mol

Synonyms:2-methoxyacridine;ACRIDINE, 2-METHOXY-;3-Methoxyacridine (European);BRN 0010165;3295-60-1;2-methoxy acridine;SCHEMBL1527016;DTXSID80186598;LS-14405

Chemical Property of Acridine, 2-methoxy-

Chemical Property:

• Vapor Pressure: 9.19E-06mmHg at 25°C
• Boiling Point: 384.2°Cat760mmHg
• Flash Point: 139.7°C
• PSA: 22.12000
• Density: 1.196g/cm³
• LogP: 3.39660
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 209.084063974
• Heavy Atom Count: 16
• Complexity: 243

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=CC3=CC=CC=C3N=C2C=C1

Technology Process of Acridine, 2-methoxy-

There total 25 articles about Acridine, 2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C21H20N2O2 (1512859-13-0) → 2-methoxyacridine (3295-60-1)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; at 80 ℃; for 24h;

DOI:10.1021/ol402732n

Reference yield: 83.0%

(4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate (1330681-27-0) + anthranil (271-58-9) → 2-methoxyacridine (3295-60-1)

Guidance literature:

With copper(I) bromide; In 1,2-dichloro-ethane; at 80 ℃; for 3h; Sealed tube;

DOI:10.2174/1570178617666200225125427

Reference yield: 80.0%

4'-methoxydiphenylamine-2-carboxaldehyde (108694-49-1) → 2-methoxyacridine (3295-60-1)

Guidance literature:

With sulfuric acid; acetic acid; at 110 ℃; for 1.5h;

DOI:10.1016/j.tet.2020.131435

upstream raw materials:

7-methoxy-1,2,3,4-tetrahydroacridine

2-methoxy-9,10-dihydroacridine

9-chloro-2-methoxyacridine

6,9-dichloro-2-methoxyacridine

Downstream raw materials:

bromo-3 methoxy-2 acridinedione-1,4

acridin-2-ol

Refernces

• 1、 Li, Jian,Lu, Xuechen,Xu, Qiuneng,Yan, Shenghu,Zhu, Shangrong. "Cu-catalyzed cascade reaction of isoxazoles with diaryliodonium salts for the synthesis of acridines". . p. 944 - 950. Retrieved 2020/12/23.
• 2、 -. "Preparation method of multi-functional group acridine compound and derivative thereof". Paragraph 0145; 0146; 0148; 0149; 0154; 0155; 0156; 0157. . Retrieved 2017/02/17.