4-amino-2-chloro-N-methylbenzamide

Base Information

• Chemical Name: 4-amino-2-chloro-N-methylbenzamide
• CAS No.: 926203-17-0
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.625
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40588291
• Wikidata: Q82480873
• Mol file: 926203-17-0.mol

Synonyms:4-amino-2-chloro-N-methylbenzamide;926203-17-0;MFCD09047559;SCHEMBL7970021;DTXSID40588291;BMB20317;BBL011783;STK946110;AKOS000103653;MCULE-6110109006;AS-43690;DB-113127;CS-0118581;EN300-50626;Z239124738

Chemical Property of 4-amino-2-chloro-N-methylbenzamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 354.475°C at 760 mmHg
• Flash Point: 168.181°C
• PSA: 55.12000
• Density: 1.282g/cm³
• LogP: 2.25390
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.0403406
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

98% ^*data from raw suppliers

4-amino-2-chloro-N-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)C1=C(C=C(C=C1)N)Cl

Technology Process of 4-amino-2-chloro-N-methylbenzamide

There total 2 articles about 4-amino-2-chloro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-amino-2-chlorobenzoic acid (2457-76-3) + methylamine (74-89-5) → 2-chloro-4-amino-N-methyl benzamide (926203-17-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield: 62.0%

2-chloro-N-methyl-4-nitro-benzamide → 2-chloro-4-amino-N-methyl benzamide (926203-17-0)

Guidance literature:

With iron; acetic acid; In ethyl acetate; for 16h; Reflux;

upstream raw materials:

4-amino-2-chlorobenzoic acid

methylamine

Refernces

• 1、 -. "IMIDAZOLIDINEDIONE COMPOUNDS AND THEIR USES". Paragraph 0131; 0132. . Retrieved 2014/10/29.