1-BroMo-2-(isopropanesulfonyl)benzene

Base Information

• Chemical Name: 1-BroMo-2-(isopropanesulfonyl)benzene
• CAS No.: 900174-43-8
• Molecular Formula: C9H11BrO2S
• Molecular Weight: 263.155
• Hs Code.: 2904909090
• Mol file: 900174-43-8.mol

Synonyms:1-BroMo-2-(isopropanesulfonyl)benzene;1-bromo-2-(isopropylsulfonyl)benzene

Chemical Property of 1-BroMo-2-(isopropanesulfonyl)benzene

Chemical Property:

• PSA: 42.52000
• LogP: 3.71200

Purity/Quality:

98% ^*data from raw suppliers

1-Bromo-2-(isopropanesulfonyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BroMo-2-(isopropanesulfonyl)benzene

There total 3 articles about 1-BroMo-2-(isopropanesulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

o-bromothiophenol (6320-02-1) + isopropyl bromide (75-26-3) → 1-bromo-2-(isopropylsulfonyl)benzene (900174-43-8)

Guidance literature:

o-bromothiophenol; isopropyl bromide; With potassium carbonate; In dichloromethane; at 38 - 40 ℃; for 5h;

With dihydrogen peroxide; In dichloromethane; at 25 - 30 ℃; for 6h;

Reference yield: 67.0%

2-isopropylsulfanyl-1-bromobenzene (245739-32-6) → 1-bromo-2-(isopropylsulfonyl)benzene (900174-43-8)

Guidance literature:

With oxone; In methanol; water; at 20 ℃; for 4h;

Reference yield:

→ 1-bromo-2-(isopropylsulfonyl)benzene (900174-43-8)

Guidance literature:

upstream raw materials:

2-isopropylsulfanyl-1-bromobenzene

o-bromothiophenol

isopropyl bromide

Downstream raw materials:

5-chloro-N²-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N⁴-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

tert-butyl 2-(2-(isopropylsulfonyl)phenyl)-1H-pyrrole-1-carboxylate

Refernces

• 1、 -. "2- [1-PHENYL-5-HYDROXY-4a-SUBSTITUTED-HEXAHYDROCYCLOPENTA [F] INDAZOL-5-YL] ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS". Page/Page column 29-30. . Retrieved 2011/05/11.