2-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

Chemical Name:2-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.:1231892-80-0
Molecular Formula:C12H17BFNO2
Molecular Weight:237.082
Hs Code.:
Mol file:1231892-80-0.mol

Synonyms:2-Fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine

Suppliers and Price of 2-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Amino-2-fluorophenylboronicAcidPinacolEster
250mg
$ 105.00

Matrix Scientific
(3-Amino-2-fluorophenyl)boronic acid pinacol ester 95%
5g
$ 1733.00

Chemcia Scientific
2-Fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine 95%
5 G
$ 795.00

Alichem
3-Amino-2-fluorophenylboronicacidpinacolester
5g
$ 1273.06

Abosyn
2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline >95%
5g
$ 800.00

A1 Biochem Labs
(3-Amino-2-fluorophenyl)boronicacidpinacolester 95%
5 g
$ 1050.00

Total 7 raw suppliers

Chemical Property of 2-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

PSA：44.48000
LogP:2.28830
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-2-fluorophenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Amino-2-fluorophenylboronic Acid Pinacol Ester is used as a reactant in the preparation of substituted heterocycles as Raf kinase inhibitors.

Technology Process of 2-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 8 articles about 2-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 73183-34-3
bis(pinacol)diborane

: 1231892-80-0
2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 100 ℃; for 23h; Inert atmosphere;

Reference yield: 69.0%

: C₁₂H₁₆BBrFNO₂

: 1231892-80-0
2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine

Guidance literature:: With potassium fluoride; palladium diacetate; In tetrahydrofuran; water; at 20 ℃; for 3h; Time; chemoselective reaction; Inert atmosphere;
DOI:10.1021/ol5028738

Reference yield:

: C₁₂H₁₆BBrFNO₂

: 348-54-9
2-Fluoroaniline

: 1231892-80-0
2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine

Guidance literature:: With palladium on activated carbon; ammonium formate; In methanol; at 60 ℃; for 0.666667h; Inert atmosphere; Schlenk technique;
DOI:10.1021/ol5028738