Technology Process of 3-Butyn-1-ol,4-(2-fluoro-3-pyridinyl)-(9CI)
There total 1 articles about 3-Butyn-1-ol,4-(2-fluoro-3-pyridinyl)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide;
bis-triphenylphosphine-palladium(II) chloride;
In
triethylamine;
at 0 ℃;
for 9h;
DOI:10.1021/jo025565n
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 100 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 34 h / 760.05 Torr
2.1: 91 percent / DMAP; Et3N / CH2Cl2 / 12 h / 20 °C
3.1: CHCl3 / 15 h / Heating
3.2: 83 percent / Et3N; AcOH / CHCl3; ethanol / 1 h / Heating
4.1: 95 percent / K2CO3 / methanol; H2O / 1 h
5.1: 87 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C
6.2: 38 percent / tetrahydrofuran; hexane / 1 h / -78 °C
With
dmap; n-butyllithium; oxalyl dichloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine;
10percent Pd/C;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; chloroform; water; ethyl acetate;
5.1: Swern oxidation;
DOI:10.1021/jo025565n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 750.08 Torr
2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 100 °C
With
palladium 10% on activated carbon; hydrogen; sodium hydride;
In
methanol; N,N-dimethyl-formamide;
