(3aS)-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole 1-oxide

Base Information

• Chemical Name: (3aS)-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole 1-oxide
• CAS No.: 1013941-83-7
• Molecular Formula: C5H9NO2S
• Molecular Weight: 147.198
• Mol file: 1013941-83-7.mol

Synonyms:(3aS)-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole 1-oxide

Chemical Property of (3aS)-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole 1-oxide

Chemical Property:

• PSA: 48.75000
• LogP: 0.86330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3aS)-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole 1-oxide

There total 1 articles about (3aS)-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → 2-(R,S)-5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2-oxide (1013941-83-7)

Guidance literature:

With 1H-imidazole; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/ol027418h

Reference yield: 78.0%

2-(R,S)-5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2-oxide (1013941-83-7) → 5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide (132635-95-1)

Guidance literature:

With ruthenium(IV) oxide; sodium periodate; In water; ethyl acetate; at 0 ℃; for 0.5h;

DOI:10.1016/S0957-4166(00)82278-8

Reference yield:

2-(R,S)-5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2-oxide (1013941-83-7) → (2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NaIO₄, RuO₂ / H₂O; ethyl acetate / 0.5 h / 0 °C

2: 1.) trifluoroacetic acid (TFA), 2.) 2 M aq. NaOH / 1.) reflux, 48 h, 2.) 90 deg C, 1 h

With ruthenium(IV) oxide; sodium hydroxide; sodium periodate; trifluoroacetic acid; In water; ethyl acetate;

DOI:10.1016/S0957-4166(00)82278-8

upstream raw materials:

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide

(2S)-2-(methoxymethyl)-1-pyrrolidine

(S)-2-(1-piperidinylmethyl)pyrrolidine

(S)-4-[(2-pyrrolidinyl)methyl]morpholine