2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid

Base Information

• Chemical Name: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid
• CAS No.: 552301-45-8
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 552301-45-8.mol

Synonyms:2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid

Chemical Property of 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid

Chemical Property:

• Boiling Point: 362.2±22.0 °C(Predicted)
• PKA: 4.42±0.10(Predicted)
• PSA: 57.53000
• Density: 1.150±0.06 g/cm3(Predicted)
• LogP: 1.58360

Purity/Quality:

97% ^*data from raw suppliers

2-(4-(2-Hydroxyethyl)phenyl)-2-methylpropanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid

There total 11 articles about 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(2-hydroxy ethyl)phenyl boronic acid (137756-89-9) + 2-chloro-2-methylpropanoic acid (594-58-1) → 2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid (552301-45-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In methanol; water; for 4h; Reagent/catalyst; Concentration; Inert atmosphere; Reflux;

Reference yield: 83.71%

2-(4-(2-hydroxyethyl)phenyl)-N,N,2-trimethylpropionamide → 2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid (552301-45-8)

Guidance literature:

With water; sodium hydroxide; pH=3 - 4; Reflux;

Reference yield:

C16H22NO5S(1-) → 2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid (552301-45-8)

Guidance literature:

With phosphoric acid; In water; at 90 ℃; for 30h; Reagent/catalyst; Temperature; Large scale;

upstream raw materials:

4-(2-hydroxy ethyl)phenyl boronic acid

2-chloro-2-methylpropanoic acid

1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane

4-bromophenethanol

Downstream raw materials:

4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester

2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester