ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoate

Base Information

• Chemical Name: ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoate
• CAS No.: 1181267-31-1
• Molecular Formula: C14H20O3
• Molecular Weight: 236.311
• Mol file: 1181267-31-1.mol

Synonyms:ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoate;4-(2-hydroxyethyl)-alpha,alpha-dimethylphenyl-acetic acid ethyl ester

Chemical Property of ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoate

Chemical Property:

• Boiling Point: 336.0±22.0 °C(Predicted)
• PKA: 14.85±0.10(Predicted)
• PSA: 46.53000
• Density: 1.059±0.06 g/cm3(Predicted)
• LogP: 2.06210

Purity/Quality:

98% ^*data from raw suppliers

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionicacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoate

There total 6 articles about ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid (552301-45-8) → 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester (1181267-31-1)

Guidance literature:

With sulfuric acid; at 80 ℃; for 22h;

Reference yield: 95.0%

C14H18O3 → 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester (1181267-31-1)

Guidance literature:

With 5% palladium on Al₂O₃; hydrogen; sodium hydroxide; In ethanol; water; at 20 ℃;

Reference yield: 92.0%

1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene (31469-16-6) + 4-bromophenethanol (4654-39-1) → 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester (1181267-31-1)

Guidance literature:

With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

upstream raw materials:

1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

4-bromophenethanol

2-methyl-2-phenylpropionic acid

ethyl 2-methyl-2-phenylpropionate

Downstream raw materials:

2-{1-[4-(2-hydroxyethyl)phenyl]-1-methylethyl}-4,5-2H-4,4-dimethyl-oxazole

2-[4-(2-methanesulfonyloxy-ethyl)-phenyl]-2-methyl-propionic acid ethyl ester