ISRIB

Base Information

Chemical Name:ISRIB
CAS No.:548470-11-7
Molecular Formula:C22H24Cl2N2O4
Molecular Weight:451.34
Hs Code.:
Mol file:548470-11-7.mol

Synonyms:ISRIB;ISRIB N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);Integrated Stress Response inhibitor;trans-N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide;2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide;N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

Suppliers and Price of ISRIB

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
ISRIB ≥98% (HPLC)
5mg
$ 99.20

Sigma-Aldrich
ISRIB ≥98% (HPLC)
25mg
$ 400.00

Crysdot
trans-ISRIB 97%
25mg
$ 325.00

Crysdot
trans-ISRIB 97%
50mg
$ 588.00

Chemenu
N,N''-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) 97%
10mg
$ 205.00

Chemenu
N,N''-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) 97%
50mg
$ 749.00

Biorbyt Ltd
ISRIB >98%
1000 mg
$ 2395.30

Biorbyt Ltd
ISRIB >98%
250 mg
$ 1208.70

Biorbyt Ltd
ISRIB >98%
100 mg
$ 615.40

Biorbyt Ltd
ISRIb >98%
5 mg
$ 173.40

Total 65 raw suppliers

Chemical Property of ISRIB

Chemical Property:

Boiling Point:719.0±60.0 °C(Predicted)
PKA:13.63±0.40(Predicted)
PSA：76.66000
Density:1.33±0.1 g/cm3(Predicted)
LogP:4.77660
Storage Temp.:2-8°C
Solubility.:DMSO: soluble1mg/mL, clear (warmed)

Purity/Quality:

99%, ^*data from raw suppliers

ISRIB ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:N
Statements: 50/53
Safety Statements: 60-61

MSDS Files:

Useful:

Description ISRIB (integrated stress response inhibitor) is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM. It was discovered in the laboratory of Peter Walter at University of California, San Francisco (UCSF) through a semi-automated screening of a large library of small molecules by Carmela Sidrauski, who decided to pursue research on it. It has been shown to inhibit eIF2α phosphorylation-induced stress granule (SG) formation. Since eIF2α phosphorylation is known to be involved in memory formation, ISRIB was tested to see whether it would be active in vivo, and was found to readily cross the blood-brain barrier, with a half-life of eight hours.
Uses ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated.
Drug interactions Drug interactions have not been studies; though ISRIB could potentially interact with drugs that have been reported to act on the integrated stress response pathway (e.g., trazodone, Halliday et al, 2017).

Technology Process of ISRIB

There total 2 articles about ISRIB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%