4-Isoxazolecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl-

Base Information

• Chemical Name: 4-Isoxazolecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl-
• CAS No.: 913535-49-6
• Molecular Formula: C₁₀H₁₄N₂O₅
• Molecular Weight: 242.232
• Mol file: 913535-49-6.mol

Synonyms:4-Isoxazolecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl-

Chemical Property of 4-Isoxazolecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl-

Chemical Property:

• PSA: 101.66000
• LogP: 2.10120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl-

There total 3 articles about 4-Isoxazolecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3-tert-Butoxycarbonylamino-5-methyl-isoxazole-4-carboxylic acid (913535-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) aq. NaOH / 1.) pyridine, room temp., 2.) MeOH

2: n-BuLi / tetrahydrofuran / from -78 deg C up to 25 deg C

3: tetrahydrofuran / 25 °C

With sodium hydroxide; n-butyllithium; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)00476-5

Reference yield:

tert-butyl (5-methylisoxazol-3-yl)carbamate (97517-66-3) → 3-tert-Butoxycarbonylamino-5-methyl-isoxazole-4-carboxylic acid (913535-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran / from -78 deg C up to 25 deg C

2: tetrahydrofuran / 25 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)00476-5

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + C9H12LiN2O3(1-)*Li(1+) → 3-tert-Butoxycarbonylamino-5-methyl-isoxazole-4-carboxylic acid (913535-49-6)

Guidance literature:

In tetrahydrofuran; at 25 ℃;

DOI:10.1016/0040-4039(96)00476-5

upstream raw materials:

carbon dioxide

di-tert-butyl dicarbonate

tert-butyl (5-methylisoxazol-3-yl)carbamate