Ethanone, 2-(3-chlorophenyl)-1-(4-chlorophenyl)-

Base Information

• Chemical Name: Ethanone, 2-(3-chlorophenyl)-1-(4-chlorophenyl)-
• CAS No.: 68968-12-7
• Molecular Formula: C14H10Cl2O
• Molecular Weight: 265.139
• Mol file: 68968-12-7.mol

Synonyms:Ethanone, 2-(3-chlorophenyl)-1-(4-chlorophenyl)-;2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one

Chemical Property of Ethanone, 2-(3-chlorophenyl)-1-(4-chlorophenyl)-

Chemical Property:

• PSA: 17.07000
• LogP: 4.41880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 2-(3-chlorophenyl)-1-(4-chlorophenyl)-

There total 5 articles about Ethanone, 2-(3-chlorophenyl)-1-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-bromo-3-chlorobenzene (108-37-2) + para-chloroacetophenone (99-91-2) → 2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one (68968-12-7)

Guidance literature:

With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; at 70 ℃; Inert atmosphere;

DOI:10.1021/ja305123v

Reference yield: 91.8%

3-chlorophenylacetic acid (1878-65-5) + chlorobenzene (108-90-7) → 2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one (68968-12-7)

Guidance literature:

3-chlorophenylacetic acid; chlorobenzene; With thionyl chloride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 2h; Large scale;

With aluminum (III) chloride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 16h; Large scale;

DOI:10.1021/acs.oprd.9b00427

Reference yield: 50.0%

Methyl 4-chlorobenzoate (1126-46-1) + 3-chlorophenylacetic acid (1878-65-5) → 2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one (68968-12-7)

Guidance literature:

3-chlorophenylacetic acid; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.583333h; Inert atmosphere;

Methyl 4-chlorobenzoate; In tetrahydrofuran; at -78 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm300354j

upstream raw materials:

chlorobenzene

3-chloro-benzeneacetyl chloride

4-chloro-benzoyl chloride

1-Chloro-3-chloromethyl-benzene