1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide

Base Information

Chemical Name:1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide
CAS No.:87203-85-8
Molecular Formula:2BrH*C₂₁H₂₈N₂O₃
Molecular Weight:518.289
Hs Code.:
DSSTox Substance ID:DTXSID301007414

Synonyms:1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide;1-(2-(3,4-Dihydroxyphenyl)-1-(4-tolyl)ethyl)-4-(2-hydroxyethyl)piperazine hydrobromide;4-(2-(4-(2-Hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-1,2-benzenediol 2HBr;87203-85-8;C21H28N2O3.2BrH;DTXSID301007414;C21-H28-N2-O3.2Br-H;LS-29974;4-{2-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-(4-methylphenyl)ethyl}benzene-1,2-diol--hydrogen bromide (1/2)

Suppliers and Price of 1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide

Chemical Property:

Vapor Pressure:2.24E-12mmHg at 25°C
Boiling Point:537.3°Cat760mmHg
Flash Point:280.1°C
Density:g/cm³
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:518.06027
Heavy Atom Count:28
Complexity:406

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(CC2=CC(=C(C=C2)O)O)N3CCN(CC3)CCO.Br.Br

Technology Process of 1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide

There total 7 articles about 1,2-Benzenediol, 4-(2-(4-(2-hydroxyethyl)-1-piperazinyl)-2-(4-methylphenyl)ethyl)-, dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 87203-80-3
1-<2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl>-4-(2-hydroxyethyl)piperazine

: 87203-85-8
4-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-p-tolyl-ethyl}-benzene-1,2-diol; hydrobromide

Guidance literature:: With hydrogen bromide; for 5h; Heating;
DOI:10.1135/cccc19831447

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 87203-85-8
4-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-p-tolyl-ethyl}-benzene-1,2-diol; hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / CHCl₃ / Heating

2: 72 percent / 46 percent hydrobromic acid / 5 h / Heating

With hydrogen bromide; In chloroform;
DOI:10.1135/cccc19831447

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 87203-85-8
4-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-p-tolyl-ethyl}-benzene-1,2-diol; hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / AlCl₃ / 1.) 15 deg C, 6.5 h, 2.) R_.T_. overnight

2: 88 percent / NaBH₄ / ethanol / 5 h / 50 - 60 °C

3: 90 percent / gaseous HCl, CaCl₂ / benzene / 4.5 h / 10 - 15 °C

4: 89 percent / CHCl₃ / Heating

5: 72 percent / 46 percent hydrobromic acid / 5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; hydrogen bromide; calcium chloride; In ethanol; chloroform; benzene;
DOI:10.1135/cccc19831447