METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE)

Base Information

• Chemical Name: METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE)
• CAS No.: 13659-98-8
• Molecular Formula: C7H10ClN3O4S2
• Molecular Weight: 299.759
• Mol file: 13659-98-8.mol

Synonyms:METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE);4-AMino-6-chloro-N3-Methyl-1,3-benzenedisulfonaMide;6-amino-4-chloro-N1-methyl-1,3-benzenedisulfonamide

Chemical Property of METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE)

Chemical Property:

• Melting Point: 97 - 99 °C
• PSA: 149.11000
• LogP: 3.31170

Purity/Quality:

98% ^*data from raw suppliers

4-Amino-6-chloro-N3-methyl-1,3-benzenedisulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Amino-6-chloro-N3-methyl-1,3-benzenedisulfonamide is a Polythiazide metabolite in dogs. 4-Amino-6-chloro-N3-methyl-1,3-benzenedisulfonamide is a reactant used in the preparation of potential diuretic agents.

Technology Process of METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE)

There total 7 articles about METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.6%

Methyclothiazid (135-07-9,96783-14-1,96783-15-2) → 4-amino-2-chloro-5-(methylsulfamyl)benzenesulfonamide (13659-98-8)

Guidance literature:

With sodium hydroxide; In water; reflux, 2 h; room temperature, 20 h;

DOI:10.1002/jps.2600700324

Reference yield:

6-chloro-2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (89813-57-0) → 4-amino-2-chloro-5-(methylsulfamyl)benzenesulfonamide (13659-98-8)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/ja01490a028

Reference yield:

chloraminophenamide (121-30-2) → 4-amino-2-chloro-5-(methylsulfamyl)benzenesulfonamide (13659-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 h / 180 °C

2: NaH / dimethylformamide / 1 h / 70 °C

3: aq. NaOH / Heating

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ja01490a028

upstream raw materials:

6-chloro-2-methyl-7-methylsulfamoyl-1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid

6-chloro-2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

Methyclothiazid

5-Chlor-2.4-bis-methylsulfamoyl-anilin

Downstream raw materials:

Methyclothiazid

6-chloro-2-methyl-3-(6-methyl-cyclohex-3-enyl)-1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid

Refernces

• 1、 -. "SUBSTITUTED 4-PHENOXY OR 4-PHENYLTHIO PROLINES". . . Retrieved 2008/06/13.