(2'-Methyl[1,1'-biphenyl]-2-yl)methanamine

Base Information

• Chemical Name: (2'-Methyl[1,1'-biphenyl]-2-yl)methanamine
• CAS No.: 153850-89-6
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• Hs Code.: 2921499090
• DSSTox Substance ID: DTXSID201283396
• Mol file: 153850-89-6.mol

Synonyms:(2'-Methyl[1,1'-biphenyl]-2-yl)methanamine;153850-89-6;[2-(2-methylphenyl)phenyl]methanamine;(2'-Methyl-[1,1'-biphenyl]-2-yl)methanamine;(2/'-METHYL[1,1/'-BIPHENYL]-2-YL)METHANAMINE;2'-METHYL-BIPHENYL-2-METHANAMINE;SCHEMBL2482120;DTXSID201283396;AKOS002683533;2'-Methyl[1,1'-biphenyl]-2-methanamine;BB 0251766;CS-0281904;C77927;EN300-25118701

Chemical Property of (2'-Methyl[1,1'-biphenyl]-2-yl)methanamine

Chemical Property:

• PSA: 26.02000
• LogP: 3.82100
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 197.120449483
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

98%min ^*data from raw suppliers

(2'-Methyl[1,1'-biphenyl]-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C2=CC=CC=C2CN

Technology Process of (2'-Methyl[1,1'-biphenyl]-2-yl)methanamine

There total 4 articles about (2'-Methyl[1,1'-biphenyl]-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(o-Tolyl)benzonitrile (157366-46-6) → (2'-methylbiphenyl-2-yl)methanamine (153850-89-6)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.07.026

Reference yield:

2-bromobenzylamine (3959-05-5) + 2-Methylphenylboronic acid (16419-60-6) → (2'-methylbiphenyl-2-yl)methanamine (153850-89-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 24h; Glovebox;

DOI:10.1021/acs.joc.0c01390

Reference yield:

2-Methylphenylboronic acid (16419-60-6) → (2'-methylbiphenyl-2-yl)methanamine (153850-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux

2: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

DOI:10.1016/j.bmc.2014.07.026

upstream raw materials:

2-(o-Tolyl)benzonitrile

2-Methylphenylboronic acid

2-iodobenzonitrile

2-bromobenzylamine

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