4-Tetrahydropyranyloxy-butan-2-one

Base Information

• Chemical Name: 4-Tetrahydropyranyloxy-butan-2-one
• CAS No.: 20705-59-3
• Molecular Formula: C9H16O3
• Molecular Weight: 172.22154
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID00415650
• Nikkaji Number: J1.270.043A
• Mol file: 20705-59-3.mol

Synonyms:20705-59-3;4-TETRAHYDROPYRANYLOXY-BUTAN-2-ONE;4-(oxan-2-yloxy)butan-2-one;4-Tetrahydropyranyloxy-butan-2-one 90%;4-((tetrahydro-2H-pyran-2-yl)oxy)butan-2-one;4-[(Oxan-2-yl)oxy]butan-2-one;ghl.PD_Mitscher_leg0.426;starbld0005688;SCHEMBL8105477;DTXSID00415650;AKOS006326891;NCGC00161067-01;FT-0675052;4-(Tetrahydro-2H-pyran-2-yloxy)-2-butanone;4-Tetrahydropyranyloxy-butan-2-one 90per cent;J-013535

Chemical Property of 4-Tetrahydropyranyloxy-butan-2-one

Chemical Property:

• Boiling Point: 64-70°C@0.55mmHg.
• PSA: 35.53000
• LogP: 1.50870
• Storage Temp.: -20°C Freezer
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 172.109944368
• Heavy Atom Count: 12
• Complexity: 145

Purity/Quality:

98%Min ^*data from raw suppliers

4-Tetrahydropyranyloxy-butan-2-one90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)CCOC1CCCCO1
• Uses: 4-Tetrahydropyranyloxy-butan-2-one 90% (cas# 20705-59-3) is a compound useful in organic synthesis.

Technology Process of 4-Tetrahydropyranyloxy-butan-2-one

There total 10 articles about 4-Tetrahydropyranyloxy-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-dihydro-2H-pyran (110-87-2) + 1-Hydroxy-3-butanone (590-90-9) → 4-(tetrahydropyran-2-yloxy)butan-2-one (20705-59-3)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2015.09.014

Reference yield: 70.0%

tributyl(4-((tetrahydro-2H-pyran-2-yl)oxy)but-1-en-2-yl)stannane → 4-(tetrahydropyran-2-yloxy)butan-2-one (20705-59-3)

Guidance literature:

With triethylamine; copper(II) trifluoroacetate hydrate name...; In dimethyl sulfoxide; at 45 - 50 ℃; Inert atmosphere;

DOI:10.1002/anie.201701391

Reference yield: 56.0%

2-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethoxy]-tetrahydro-pyran (97250-23-2) → 4-(tetrahydropyran-2-yloxy)butan-2-one (20705-59-3)

Guidance literature:

dichloro bis(acetonitrile) palladium(II); In acetone; Ambient temperature;

DOI:10.1016/S0040-4039(00)89114-5

upstream raw materials:

3,4-dihydro-2H-pyran

1-Hydroxy-3-butanone

2-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethoxy]-tetrahydro-pyran

TETRAHYDROPYRANE

Downstream raw materials:

5-(cyclopropylidene)pentan-1-ol

4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol