6-amino-7-methoxyquinazolin-4(3H)-one

Base Information

• Chemical Name: 6-amino-7-methoxyquinazolin-4(3H)-one
• CAS No.: 130017-55-9
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.18666
• Mol file: 130017-55-9.mol

Synonyms:6-amino-7-methoxyquinazolin-4(3H)-one

Chemical Property of 6-amino-7-methoxyquinazolin-4(3H)-one

Chemical Property:

• Melting Point: 289-291 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• Boiling Point: 425.9±55.0 °C(Predicted)
• PKA: 3.89±0.20(Predicted)
• PSA: 81.00000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 1.09510
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Amino-7-methoxyquinazolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-amino-7-methoxyquinazolin-4(3H)-one

There total 8 articles about 6-amino-7-methoxyquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-methoxy-6-nitroquinazolin-4(3H)-one (1012057-47-4) → 6-Amino-7-methoxy-4(3H)-quinazolinone (130017-55-9)

Guidance literature:

7-methoxy-6-nitroquinazolin-4(3H)-one; With hydrogenchloride; iron; In ethanol; water; acetic acid; at 100 ℃; for 1h;

With ammonia; In ethanol; water; acetic acid;

DOI:10.1021/acs.jmedchem.6b00883

Reference yield: 65.0%

6-Acetamido-7-methoxy-4(3H)-quinazolinone (130017-54-8) → 6-Amino-7-methoxy-4(3H)-quinazolinone (130017-55-9)

Guidance literature:

With sodium hydroxide; at 90 ℃; for 15h;

DOI:10.1248/cpb.38.1591

Reference yield:

3-acetamido-4-methoxybenzoic acid (130017-51-5) → 6-Amino-7-methoxy-4(3H)-quinazolinone (130017-55-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 74 percent / NO₂BF₄ / acetonitrile / 0.17 h / 0 - 5 °C

2: SOCl₂ / 0.5 h / Heating

3: NH₄OH

4: H₂ / 10percent Pd/C / methanol / 3 h / 40 °C / 760 Torr

5: 4 h / 100 °C

6: 65 percent / 1 N NaOH / 15 h / 90 °C

With ammonium hydroxide; sodium hydroxide; thionyl chloride; nitronium tetrafluoborate; hydrogen; palladium on activated charcoal; In methanol; acetonitrile;

DOI:10.1248/cpb.38.1591

upstream raw materials:

6-Acetamido-7-methoxy-4(3H)-quinazolinone

3-acetamido-4-methoxybenzoic acid

5-acetylamino-4-methoxy-2-nitrobenzoic acid

5-Acetamido-4-methoxy-2-nitrobenzamide