4-Hydroxy-7-methoxy-6-nitroquinazoline

Base Information

• Chemical Name: 4-Hydroxy-7-methoxy-6-nitroquinazoline
• CAS No.: 1012057-47-4
• Molecular Formula: C9H7N3O4
• Molecular Weight: 221.172
• Hs Code.: 2933990090
• Mol file: 1012057-47-4.mol

Synonyms:4-HYDROXY-7-METHOXY-6-NITROQUINAZOLINE;7-Methoxy-6-nitroquinazolin-4(3H)-one

Chemical Property of 4-Hydroxy-7-methoxy-6-nitroquinazoline

Chemical Property:

• Boiling Point: 443.8±55.0 °C(Predicted)
• PKA: -1.91±0.20(Predicted)
• PSA: 101.06000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 1.77540

Purity/Quality:

98%min ^*data from raw suppliers

7-Methoxy-6-nitroquinazolin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-7-methoxy-6-nitroquinazoline

There total 3 articles about 4-Hydroxy-7-methoxy-6-nitroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2) → 7-methoxy-6-nitroquinazolin-4(3H)-one (1012057-47-4)

Guidance literature:

With sodium; at 100 ℃; for 18h;

DOI:10.1021/jm9503613

Reference yield: 87.6%

sodium methylate (124-41-4) + 7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2) → 7-methoxy-6-nitroquinazolin-4(3H)-one (1012057-47-4)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 20h;

Reference yield: 77.0%

7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2) → 7-methoxy-6-nitroquinazolin-4(3H)-one (1012057-47-4)

Guidance literature:

With methanol; sodium; at 100 ℃; for 20h;

upstream raw materials:

methanol

7-chloro-6-nitro-4(3H)-quinazolinone

sodium methylate

Downstream raw materials:

Methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)propanoate

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine hydrochloride

N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide

Refernces

• 1、 Cai, Xiong,Zhai, Hai-Xiao,Wang, Jing,Forrester, Jeffrey,Qu, Hui,Yin, Ling,Lai, Cheng-Jung,Bao, Rudi,Qian, Changgeng. "Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N- hydroxyheptanamide (CUDC-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer". supporting information; experimental part. p. 2000 - 2009. Retrieved 2010/07/17.
• 2、 -. "TARTRATE SALTS OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY". Page/Page column 74. . Retrieved 2009/04/24.