cis-Ethyl 4-aMinocyclohexanecarboxylate hydrochloride

Base Information

• Chemical Name: cis-Ethyl 4-aMinocyclohexanecarboxylate hydrochloride
• CAS No.: 61367-17-7
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.7
• Mol file: 61367-17-7.mol

Synonyms:cis-Ethyl 4-aMinocyclohexanecarboxylate hydrochloride;Cis-4-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride

Chemical Property of cis-Ethyl 4-aMinocyclohexanecarboxylate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.56930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Ethylcis-4-AminocyclohexanecarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl cis-4-Aminocyclohexanecarboxylate Hydrochloride is used as a reagent in the synthesis of arylpiperazinylalkyl and arylpiperazinylalkylthio quinazolinones as dual 5-HT1a agonists and 5-HT3 antagonists for use in treating irritable bowel syndrome (IBS).

Technology Process of cis-Ethyl 4-aMinocyclohexanecarboxylate hydrochloride

There total 15 articles about cis-Ethyl 4-aMinocyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1r,4r)-4-aminocyclohexanecarboxylic acid + ethanol (64-17-5) → (1r,4r)-ethyl 4-aminocyclohexanecarboxylate hydrochloride (2084-28-8,61367-17-7)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃; for 20h;

Reference yield: 99.0%

(1r,4r)-4-aminocyclohexanecarboxylic acid + ethanol (64-17-5) → (1 r,4r)-ethyl 4-aminocyclohexanecarboxylate hydrochloride (2084-28-8,61367-17-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 60 ℃; for 20h;

Reference yield: 96.0%

cis-4-aminocyclohexylcarboxylic acid + ethanol (64-17-5) → cis-ethyl 4-aminocyclohexanecarboxylate hydrochloride (2084-28-8,61367-17-7)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃;

upstream raw materials:

ethyl 4-amino-1-cyclohexanecarboxylate

ethyl trans-4-aminocyclohexanecarboxylate

ethanol

trans-4-aminocyclohexanecarboxylic acid

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES". Paragraph 1472-1473. . Retrieved 2019/06/07.
• 2、 -. "TETRACYCLIC CDK9 KINASE INHIBITORS". Paragraph 1404. . Retrieved 2015/09/22.