N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

Base Information

Chemical Name:N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine
CAS No.:1057666-90-6
Molecular Formula:C₃₂H₃₉F₆N₅O₂S
Molecular Weight:671.75
Hs Code.:

N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

Synonyms:N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

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Chemical Property of N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

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Technology Process of N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

There total 12 articles about N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1006599-60-5
N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

: 160376-84-1
1-[3,5-bis(trifluoromethyl)phenyl]ethyl bromide

: 1057666-90-6
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

Guidance literature:: N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 50 ℃; for 0.5h;

1-[3,5-bis(trifluoromethyl)phenyl]ethyl bromide; In N,N-dimethyl-formamide; at -78 - 20 ℃; for 12h;

Reference yield:

: 1006599-55-8
3-bromo-6-methoxy-2-((methoxymethoxy)methyl)pyridine

: 1057666-90-6
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos / tetrahydrofuran / 0.05 h / 135 °C / microwave irradiation (500 W)

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 19 h / 50 °C

4.1: manganese(IV) oxide / chloroform / 22 h / 55 °C

5.1: 1,2-dichloro-ethane / 0.17 h / 20 °C

5.2: 12 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 50 °C

6.2: 12 h / -78 - 20 °C

With hydrogenchloride; manganese(IV) oxide; water; sodium tris(acetoxy)borohydride; sodium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; 1,4-dioxane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 623942-84-7
2-(hydroxymethyl)-3-bromo-6-methoxypyridine

: 1057666-90-6
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos / tetrahydrofuran / 0.05 h / 135 °C / microwave irradiation (500 W)

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 19 h / 50 °C

5.1: manganese(IV) oxide / chloroform / 22 h / 55 °C

6.1: 1,2-dichloro-ethane / 0.17 h / 20 °C

6.2: 12 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 50 °C

7.2: 12 h / -78 - 20 °C

With hydrogenchloride; manganese(IV) oxide; water; sodium tris(acetoxy)borohydride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;