AF38469

Base Information

• Chemical Name: AF38469
• CAS No.: 1531634-31-7
• Molecular Formula: C15H11F3N2O3
• Molecular Weight: 324.25
• Mol file: 1531634-31-7.mol

Synonyms:AF38469

Chemical Property of AF38469

Chemical Property:

• Boiling Point: 392.3±42.0 °C(Predicted)
• PKA: 2.83±0.36(Predicted)
• PSA: 79.29000
• Density: 1.448±0.06 g/cm3(Predicted)
• LogP: 3.43230

Purity/Quality:

99%, ^*data from raw suppliers

AF38469 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AF38469

There total 3 articles about AF38469 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

2-(6-methylpyridin-2-yl)-5-trifluoromethylisoindole-1,3-dione (1529805-29-5) → C15H11F3N2O3 (1529805-43-3) + 2-((6-methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid (1531634-31-7)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) + 5-trifluoromethylbenzofuran-1,3-dione (26238-14-2) → C15H11F3N2O3 (1529805-43-3) + 2-((6-methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid (1531634-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 5 h / Reflux

2: lithium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

With acetic acid; lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2013.11.046

Reference yield:

→ 2-((6-methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid (1531634-31-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

upstream raw materials:

2-Amino-6-methylpyridine

5-trifluoromethylbenzofuran-1,3-dione

2-(6-methylpyridin-2-yl)-5-trifluoromethylisoindole-1,3-dione

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