26238-14-2

Upstream product

• 835-58-5 4-(trifluoromethyl)phthalic acid 
• 78164-31-5 1,2-dimethyl-4-(trifluoromethyl)benzene 

Downstream Products

• 1997-41-7 5-trifluoromethylphthalimide 
• 342638-03-3 5-trifluoromethyl-2,3-dihydro-1H-isoindole 
• 927203-45-0 2-benzyl-5-trifluoromethyl-isoindole-1,3-dione 
• 1483-45-0 4-trifluoromethylphthalodinitrile 
• 20036-05-9 4-trifluoromethylphthalamide 
• 1276673-19-8 2-((1S,4S)-4-fluoro-4-(3-(trifluoromethyl)phenylsulfonyl)cyclohexyl)-5-(trifluoromethyl)isoindoline-1,3-dione 
• 1334537-78-8 N,N'-[(phenylimino)di-4,1-phenylene]bis-(5-trifluoromethyl phthalimide) 
• 1529805-43-3 C₁₅H₁₁F₃N₂O₃ 
• 1531634-31-7 2-((6-methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid 
• 1529805-61-5 N-(6-methoxypyridin-2-yl)-5-trifluoromethylphthalamic acid 
• 58230-75-4 N-(4-amino-o-tolyl)-4-trifluoromethylphthalimide 
• 58230-74-3 N-(4-nitro-o-tolyl)-4-trifluoromethylphthalimide 
• 927203-46-1 2-benzyl-5-trifluoromethyl-2H-isoindole 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS

The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

Organic non-fullerene electron acceptor material, preparation method and application thereof

The invention relates to the field of organic solar cell materials, in particular to an organic non-fullerene electron acceptor material, a preparation method and application thereof. According to the organic non-fullerene electron acceptor material, strong electron-withdrawing trifluoromethyl groups are introduced to two ends of a non-fullerene acceptor molecule, so that the LUMO energy level of a fused ring electron-rich parent nucleus can be effectively reduced, the electron transmission capability of the acceptor material is improved, and the introduction of trifluoromethyl can also bring closer acceptor molecule accumulation so as to facilitate the improvement of the electron mobility. The organic non-fullerene electron acceptor material provided by the invention has good solubility and film-forming property, strong visible light or near-infrared light absorption performance and high electron mobility, can be used for preparing organic solar cells with high energy conversion efficiency, and is a potential acceptor material.

Discovery of potent indenoisoquinoline topoisomerase i poisons lacking the 3-nitro toxicophore

3-Nitroindenoisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer cells. The undesirable nitro toxicophore could hypothetically be replaced by other functional groups that would retain the desired biological activities and minimize potential safety risks. Eleven series of indenoisoquinolines bearing 3-nitro bioisosteres were synthesized. The molecules were evaluated in the Top1-mediated DNA cleavage assay and in the National Cancer Institute's 60 cell line cytotoxicity assay. The data reveal that fluorine and chlorine may substitute for the 3-nitro group with minimal loss of Top1 poisoning activity. The new information gained from these efforts can be used to design novel indenoisoquinolines with improved safety.

New donor-acceptor oligoimides for high-performance nonvolatile memory devices

We report the synthesis, optoelectronic properties, and electrical switching memory characteristics of three new donor-acceptor oligoimides consisting of the electron-donating moieties (triphenylamine or carbazole) and electron-withdrawing phthalimide moieties. The influence of different donor (D)-acceptor (A) arrangements, including D-A-D and A-D-A structures, on the electrical properties was explored. Devices based on D-A-D oligoimides revealed a reversible nonvolatile negative-differential-resistance (NDR) characteristic and excellent stability during operation. Without applying voltage stress, the on and off states of the devices showed no obvious degradation for an operation time of 10 s and 108 read pulses. However, the devices prepared from the A-D-A oligoimide showed only the insulating properties. The different memory characteristic was probably because the terminal donor moieties in the D-A-D structure might facilitate the injection and transporting of the holes. Besides, the D-A-D oligoimide with triphenylamine groups exhibited an on/off ratio of 104, 2 orders of magnitude higher than that with carbazole groups. The mechanism related to electrical switching properties was elucidated through molecular simulation. Thus the significance of D-A-D structure on tuning memory characteristics for memory device applications was revealed.

Dual fluorescent N-Aryl-2,3-naphthalimides: Applications in ratiometric DNA detection and white organic light-emitting devices

A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophysical model this matrix yielded nine new DF dyes out of a possible ten compounds. From this set of nine DF dyes, 4-fluoronaphthalic amide (37) was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.

Transnitrosation of thiols from aliphatic N-nitrosamines: S-nitrosation and indirect generation of nitric oxide

S-Nitrosothiols and heme nitrosyl species are nitric oxide (NO)-derived metabolites that provide an endogenous reservoir of NO and also play roles in protein S-nitrosation, that is, transnitrosation of thiols (or thiolates) in proteins, thereby regulating protein functions and signal transduction pathways. Intriguingly, endogenous N-nitrosamines are present in similar abundance to S-nitrosothiols, and though they are thought to play similar physiological roles to S-nitrosothiols, their transnitrosation reactivities and their contribution to biological events are little understood. Herein we report aliphatic N-nitroso derivatives of 7-azabicyclo[2.2.1]heptanes, which do not act as NO donors themselves, but can transnitrosate thiols. On the basis of the calculated activation energies of transnitrosation and the aorta smooth-muscle relaxation activities of these N-nitrosamines, we present a possible scenario of S-transnitrosation from aliphatic N-nitrosamines, leading to indirect generation of NO. Copyright

Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them

The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.

N- ((3-OXO2, 3-DIHYDRO-1H-ISOINDOL-1-YL) ACETYL) GUANIDINE DERIVATIVES AS NHE-1 INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS

Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them. The present invention relates to the novel isoindolone derivatives of the Formula (I), in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.