tert-Butyl 3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Base Information

• Chemical Name: tert-Butyl 3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
• CAS No.: 1174068-78-0
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.287
• Mol file: 1174068-78-0.mol

Synonyms:tert-Butyl 3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate;tert-butyl 1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-2-carboxylate

Chemical Property of tert-Butyl 3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Chemical Property:

• PSA: 34.47000
• LogP: 2.17670
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3,4-Dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

There total 2 articles about tert-Butyl 3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-aminoethyl)pyrrole (29709-35-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + di-tert-butyl dicarbonate (24424-99-5) → 3,4-Dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester (1174068-78-0)

Guidance literature:

1-(2-aminoethyl)pyrrole; formaldehyd; With trifluoroacetic acid; In ethanol; water; at 25 - 50 ℃; for 4.25h;

With sodium hydrogencarbonate; In water; ethyl acetate;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 1,2,3,4-Tetrahydropyrrolo<1,2-a>pyrazine (71257-38-0) → 3,4-Dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester (1174068-78-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 16h; Product distribution / selectivity;

Reference yield: 60.0%

3,4-Dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester (1174068-78-0) → C13H18N2O3 (1174068-79-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; at 0 - 25 ℃; for 0.75h; Product distribution / selectivity;

upstream raw materials:

di-tert-butyl dicarbonate

1,2,3,4-Tetrahydropyrrolo<1,2-a>pyrazine

1-(2-aminoethyl)pyrrole

formaldehyd

Downstream raw materials:

C₁₃H₁₈N₂O₃

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