1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester

Base Information

Chemical Name:1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester
CAS No.:51842-50-3
Molecular Formula:C14H13NO4
Molecular Weight:259.25732
Hs Code.:2933990090
Mol file:51842-50-3.mol

Synonyms:1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester;ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate;4-(1H-indol-3-yl)-2,4-diketo-butyric acid ethyl ester;4-(1H-indol-3-yl)-2,4-dioxobutanoic acid ethyl ester;Butanoic acid, 4-(2-indolyl)-2,4-dioxo-, ethyl ester

Suppliers and Price of 1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate
500mg
$ 285.00

Matrix Scientific
Ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate
1g
$ 339.00

Matrix Scientific
Ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate
5g
$ 955.00

Crysdot
Ethyl4-(1H-indol-3-yl)-2,4-dioxobutanoate 97%
5g
$ 904.00

Crysdot
Ethyl4-(1H-indol-3-yl)-2,4-dioxobutanoate 97%
1g
$ 320.00

Chemenu
Ethyl4-(1H-indol-3-yl)-2,4-dioxobutanoate 95%+
1g
$ 302.00

Chemenu
Ethyl4-(1H-indol-3-yl)-2,4-dioxobutanoate 95%+
5g
$ 853.00

American Custom Chemicals Corporation
1H-INDOLE-3-BUTANOIC ACID, ALPHA,GAMMA-DIOXO-, ETHYL ESTER 95.00%
5MG
$ 500.36

AK Scientific
Ethyl4-(1H-indol-3-yl)-2,4-dioxobutanoate
500mg
$ 434.00

aablocks
Ethyl4-(1h-indol-3-yl)-2,4-dioxobutanoate
5g
$ 1813.00

Total 5 raw suppliers

Chemical Property of 1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester

Chemical Property:

Melting Point:192 °C(Solv: water (7732-18-5); ethanol (64-17-5))
Boiling Point:470.6±25.0 °C(Predicted)
PKA:6.57±0.46(Predicted)
PSA：76.23000
Density:1.296±0.06 g/cm3(Predicted)
LogP:1.87290

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester

There total 2 articles about 1H-indole-3-butanoic acid, alpha,gamma-dioxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 703-80-0
3-acetylindole

: 95-92-1
oxalic acid diethyl ester

: 51842-50-3
ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate

Guidance literature:: With sodium ethanolate; at 75 ℃; for 2h;
DOI:10.1007/s12272-011-0301-2

Reference yield:

: 51842-50-3
ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate

Guidance literature:: 3-Acetylindol, (COOEt)2, NaOMe;
DOI:10.1007/BF00470345

Reference yield:

: 51842-50-3
ethyl 4-(1H-indol-3-yl)-2,4-dioxobutanoate

: 1311157-88-6
ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate; acetic acid / isopropyl alcohol / 2 h / Cooling

2.1: potassium bromide; potassium hydroxide / dimethyl sulfoxide / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 10 °C

3.2: 20 °C

With sodium hydride; hydrazine hydrate; acetic acid; potassium bromide; potassium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s12272-011-0301-2