N4-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE

Base Information

• Chemical Name: N4-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE
• CAS No.: 95261-09-9
• Molecular Formula: C18H18N4O4
• Molecular Weight: 354.365
• Mol file: 95261-09-9.mol

Synonyms:N4-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE;N6-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE;N-[7-(2-Deoxy-beta-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzamide

Chemical Property of N4-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE

Chemical Property:

• PSA: 109.50000
• LogP: 1.39730

Purity/Quality:

97% ^*data from raw suppliers

N6-Benzoyl-7-deaza-2'-deoxyadenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N4-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE

There total 1 articles about N4-BENZOYL-7-DEAZA-2'-DEOXYADENOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzoyl chloride (98-88-4) + 2'-deoxy-7-deazaadenosine (60129-59-1) → 4-benzoylamino-7-(2-desoxy-β-Derythro-pentofuranosyl)-7H-pyrrolo<2,3-d> yrimidin (95261-09-9)

Guidance literature:

With chloro-trimethyl-silane; Ambient temperature; 1.) pyridine, 2 h, 2.) 2 h;

DOI:10.1016/S0040-4020(01)96795-X

Reference yield: 88.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 4-benzoylamino-7-(2-desoxy-β-Derythro-pentofuranosyl)-7H-pyrrolo<2,3-d> yrimidin (95261-09-9) → N-{7-[(2R,4S,5R)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-benzamide (905581-25-1)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 76.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 4-benzoylamino-7-(2-desoxy-β-Derythro-pentofuranosyl)-7H-pyrrolo<2,3-d> yrimidin (95261-09-9) → N-(7-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide (90335-57-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In pyridine; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96795-X

upstream raw materials:

benzoyl chloride

2'-deoxy-7-deazaadenosine

Downstream raw materials:

N-(7-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide

2'-deoxy-7-deazaadenosine

4-benzoylamino-3'-O-(tert-butyldimethylsilyl)-7-(2-desoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin

4-benzoylamino-3'-O-(tert-butyldimethylsilyl)-7-(2-desoxy-β-D-erythro-pentofuranosyl)-5'O-(4,4'-dimethoxytrityl)-7H-pyrrolo<2,3-d>pyrimidin

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