4-Amino-α,α-dimethylbenzeneacetic acid methyl ester

Base Information

• Chemical Name: 4-Amino-α,α-dimethylbenzeneacetic acid methyl ester
• CAS No.: 54815-23-5
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol file: 54815-23-5.mol

Synonyms:4-Amino-α,α-dimethylbenzeneacetic acid methyl ester;Methyl 2-(4-aminophenyl)-2-methylpropanoate

Chemical Property of 4-Amino-α,α-dimethylbenzeneacetic acid methyl ester

Chemical Property:

• Melting Point: 80-84 °C
• Boiling Point: 297.5±23.0 °C(Predicted)
• PKA: 4.04±0.10(Predicted)
• PSA: 52.32000
• Density: 1.083±0.06 g/cm3(Predicted)
• LogP: 2.30060

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-?(4-?Aminophenyl)?-?2-?methylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-?(4-?Aminophenyl)?-?2-?methylpropanoate can be used as reactant/reagent in preparation of amide compounds having RORyt inhibitory effect.

Technology Process of 4-Amino-α,α-dimethylbenzeneacetic acid methyl ester

There total 5 articles about 4-Amino-α,α-dimethylbenzeneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 2-methyl-2-(4-nitrophenyl)propanoate (59115-08-1) → methyl α,α-dimethyl-4-aminobenzene-1-acetate (54815-23-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol;

DOI:10.1016/j.bmcl.2017.08.005

Reference yield: 80.0%

→ methyl α,α-dimethyl-4-aminobenzene-1-acetate (54815-23-5)

Guidance literature:

Reference yield: 58.0%

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene (31469-15-5) + 4-chloro-aniline (106-47-8) → methyl α,α-dimethyl-4-aminobenzene-1-acetate (54815-23-5)

Guidance literature:

With triethylamine; In acetonitrile; for 3h; Irradiation;

DOI:10.1021/jo034375p

upstream raw materials:

methyl 2-methyl-2-(4-nitrophenyl)propanoate

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

4-chloro-aniline

2-(4-(benzyloxycarbonylamino)phenyl)-2-methylpropanoic acid methyl ester

Downstream raw materials:

2-(4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-phenyl)-2-methyl-propionic acid methyl ester

methyl 2-[4-(4-benzylpiperazin-1-yl)phenyl]-2-methylpropanoate

2-(N,N-dimethyl-4-aminophenyl)-2-methylpropionic acid methyl ester

2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

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