2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Base Information

Chemical Name:2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid
CAS No.:1375701-89-5
Molecular Formula:C₂₆H₂₆ClN₅O₂
Molecular Weight:475.978
Hs Code.:

Synonyms:2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Suppliers and Price of 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

There total 7 articles about 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375702-24-1
methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

: 1375701-89-5
2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Guidance literature:: methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate; With water; sodium hydroxide; In methanol; at 50 ℃; Reflux;

With hydrogenchloride; In water; pH=7;

Reference yield:

: 59115-08-1
methyl 2-methyl-2-(4-nitrophenyl)propanoate

: 1375701-89-5
2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

2.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 110 °C

3.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 36 h / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 110 °C

5.1: sodium hydroxide; water / methanol / 50 °C / Reflux

5.2: pH 7

With water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; palladium 10% on activated carbon; palladium hydroxide, 20 wt% on carbon; In methanol; ethanol; ISOPROPYLAMIDE;

Reference yield:

: 42206-47-3
2-methyl-2-(4-nitro-phenyl)-propionic acid

: 1375701-89-5
2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

3.1: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 110 °C

4.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 36 h / 760.05 Torr

5.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 110 °C

6.1: sodium hydroxide; water / methanol / 50 °C / Reflux

6.2: pH 7

With hydrogenchloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; palladium 10% on activated carbon; palladium hydroxide, 20 wt% on carbon; In methanol; ethanol; ISOPROPYLAMIDE;