methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

Base Information

Chemical Name:methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate
CAS No.:1375702-24-1
Molecular Formula:C₂₇H₂₈ClN₅O₂
Molecular Weight:490.005
Hs Code.:

Synonyms:methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

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Chemical Property of methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

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Technology Process of methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

There total 6 articles about methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 337920-73-7
5-chloro-2-(6-chloropyridin-3-yl)-1H-benzimidazole

: 1095540-43-4
methyl 2-methyl-2-[4-(piperazin-1-yl)phenyl]propanoate

: 1375702-24-1
methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 110 ℃;

Reference yield:

: 59115-08-1
methyl 2-methyl-2-(4-nitrophenyl)propanoate

: 1375702-24-1
methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

2: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 110 °C

3: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 36 h / 760.05 Torr

4: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 110 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium 10% on activated carbon; palladium hydroxide, 20 wt% on carbon; In methanol; ethanol; ISOPROPYLAMIDE;

Reference yield:

: 42206-47-3
2-methyl-2-(4-nitro-phenyl)-propionic acid

: 1375702-24-1
methyl 2-(4-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

3: potassium carbonate; sodium iodide / ISOPROPYLAMIDE / 110 °C

4: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 36 h / 760.05 Torr

5: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 110 °C

With hydrogenchloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium 10% on activated carbon; palladium hydroxide, 20 wt% on carbon; In methanol; ethanol; ISOPROPYLAMIDE;