(4-AMino-3-iodo-phenyl)-acetic acid ethyl ester

Base Information

• Chemical Name: (4-AMino-3-iodo-phenyl)-acetic acid ethyl ester
• CAS No.: 405267-73-4
• Molecular Formula: C10H12INO2
• Molecular Weight: 305.115
• Mol file: 405267-73-4.mol

Synonyms:(4-AMino-3-iodo-phenyl)-acetic acid ethyl ester;ethyl 2-(4-amino-3-iodophenyl)acetate

Chemical Property of (4-AMino-3-iodo-phenyl)-acetic acid ethyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 2.56020

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl (4-amino-3-iodophenyl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-AMino-3-iodo-phenyl)-acetic acid ethyl ester

There total 1 articles about (4-AMino-3-iodo-phenyl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (4-amino-3,5-dibromophenyl)acetate (5438-70-0) → (4-amino-3-iodophenyl)acetic acid ethyl ester (405267-73-4)

Guidance literature:

With N-iodo-succinimide; In acetonitrile; Reflux; Inert atmosphere;

Reference yield: 93.0%

(4-amino-3-iodophenyl)acetic acid ethyl ester (405267-73-4) + toluenesulfonic acid monohydrate + ethyl acetoacetate (141-97-9) → 3-(4-ethoxycarbonylmethyl-2-iodo-phenylamino)but-2-enoic acid ethyl ester

Guidance literature:

In benzene;

Reference yield: 77.0%

(4-amino-3-iodophenyl)acetic acid ethyl ester (405267-73-4) → 2-(4-amino-3-iodophenyl)ethanol (459449-11-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

DOI:10.1002/cmdc.201300319

upstream raw materials:

ethyl (4-amino-3,5-dibromophenyl)acetate

Downstream raw materials:

6-bromo-5-{[2-(3-methoxy-phenyl)-ethylcarbamoyl]-methyl}-2-methyl-1H-indole-3-carboxylic acid ethyl ester

6-bromo-2-ethyl-5-{[2-(3-methoxyphenyl)ethylcarbamoyl]methyl}-1H-indole-3-carboxylic acid ethyl ester

2-(4-amino-3-iodophenyl)ethanol