2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE

Base Information

Chemical Name:2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE
CAS No.:256227-77-7
Molecular Formula:C28H29N5O3
Molecular Weight:483.57
Hs Code.:
Mol file:256227-77-7.mol

Synonyms:[1,1'-BIPHENYL]-4-CARBOXAMIDE, N-[4-HYDROXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]-2'-METHYL-4'-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-;2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE;GMC2-113

Suppliers and Price of 2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
GMC 2-113 95.00%
50MG
$ 1189.65

American Custom Chemicals Corporation
GMC 2-113 95.00%
10MG
$ 334.95

Total 1 raw suppliers

Chemical Property of 2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE

Chemical Property:

PSA：94.73000
LogP:4.80600

Purity/Quality:

98% ^*data from raw suppliers

GMC 2-113 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE

There total 3 articles about 2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBOXYLIC ACID [4-HYDROXY-3-(4-METHYL-PIPERAZIN-1-YL)-PHENYL]-AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 148672-15-5
GMC 2-29

: 256227-77-7
GMC 2-113

Guidance literature:: With aluminium trichloride; ethanethiol; In dichloromethane; at 20 ℃;
DOI:10.1021/jm990397l

Reference yield:

: 148546-79-6
4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzamide

: 256227-77-7
GMC 2-113

Guidance literature:: Multi-step reaction with 3 steps

1: B(O-i-Pr)3; n-BuLi / -78 - 20 °C

2: 72 percent / Na₂CO₃; Pd(PPh₃)4 / dimethylformamide; H₂O / 24 h / Heating

3: 85 percent / AlCl₃; EtSH / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; aluminium trichloride; Triisopropyl borate; sodium carbonate; ethanethiol; In dichloromethane; water; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: demethylation;
DOI:10.1021/jm990397l

Reference yield:

: 148547-21-1
[4-({[4-(methyloxy)-3-(4-methyl-1-piperazinyl)phenyl]amino}carbonyl)phenyl]boronic acid

: 256227-77-7
GMC 2-113

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / Na₂CO₃; Pd(PPh₃)4 / dimethylformamide; H₂O / 24 h / Heating

2: 85 percent / AlCl₃; EtSH / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; sodium carbonate; ethanethiol; In dichloromethane; water; N,N-dimethyl-formamide; 1: Substitution / 2: demethylation;
DOI:10.1021/jm990397l