2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Base Information

Chemical Name:2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
CAS No.:148672-15-5
Molecular Formula:C29H31N5O3
Molecular Weight:497.597
Hs Code.:
DSSTox Substance ID:DTXSID601105023
Nikkaji Number:J1.270.992G
Pharos Ligand ID:W5N4WM1C6BLY
ChEMBL ID:CHEMBL146735
Mol file:148672-15-5.mol

Synonyms:148672-15-5;GMC 2-29;CHEMBL146735;2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide;N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide;SCHEMBL5319425;QXLNAYIFEMXTDZ-UHFFFAOYSA-N;DTXSID601105023;BDBM50084958;NCGC00386477-01;FT-0704993;E98678;L008494;2''-Methyl-4''-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-4-carboxamide;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,3,4-oxadiazole-2-yl)[1,1'-biphenyl]-4-carboxamide

Suppliers and Price of 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
GMC 2-29 95.00%
10MG
$ 320.25

Total 2 raw suppliers

Chemical Property of 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Chemical Property:

PSA：83.73000
LogP:5.10900
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:497.24268987
Heavy Atom Count:37
Complexity:739

Purity/Quality:

99% ^*data from raw suppliers

GMC 2-29 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C

Technology Process of 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

There total 3 articles about 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 148547-21-1
[4-({[4-(methyloxy)-3-(4-methyl-1-piperazinyl)phenyl]amino}carbonyl)phenyl]boronic acid

: 3-(4'-bromo-3'-methylphenyl)-5-methyl-1,3,4-oxadiazole

: 148672-15-5
GMC 2-29

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; for 24h; Heating;
DOI:10.1021/jm990397l

Reference yield:

: 148546-79-6
4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzamide

: 148672-15-5
GMC 2-29

Guidance literature:: Multi-step reaction with 2 steps

1: B(O-i-Pr)3; n-BuLi / -78 - 20 °C

2: 72 percent / Na₂CO₃; Pd(PPh₃)4 / dimethylformamide; H₂O / 24 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; sodium carbonate; In water; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution;
DOI:10.1021/jm990397l