GMC2-118

Base Information

Chemical Name:GMC2-118
CAS No.:256227-78-8
Molecular Formula:C₂₉H₃₁N₅O₅S
Molecular Weight:561.662
Hs Code.:
Mol file:256227-78-8.mol

Synonyms:[1,1'-BIPHENYL]-4-CARBOXAMIDE, 2'-METHYL-4'-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-N-[3-(4-METHYL-1-PIPERAZINYL)-4-[(METHYLSULFONYL)OXY]PHENYL]-;GMC2-118;METHANESULFONIC ACID 4-([2'-METHYL-4'-(5-METHYL-[1,3,4]OXADIAZOL-2-YL)-BIPHENYL-4-CARBONYL]-AMINO)-2-(4-METHYL-PIPERAZIN-1-YL)-PHENYL ESTER

Suppliers and Price of GMC2-118

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
GMC 2-118 95.00%
10MG
$ 334.95

Total 1 raw suppliers

Chemical Property of GMC2-118

Chemical Property:

PSA：126.25000
LogP:5.51960

Purity/Quality:

98% ^*data from raw suppliers

GMC 2-118 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of GMC2-118

There total 4 articles about GMC2-118 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 124-63-0
methanesulfonyl chloride

: 256227-77-7
GMC 2-113

: 256227-78-8
methanesulfonic acid 4-{[2'-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carbonyl]-amino}-2-(4-methyl-piperazin-1-yl)-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -78 - 20 ℃; for 1h;
DOI:10.1021/jm990397l

Reference yield:

: 148546-79-6
4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzamide

: 256227-78-8
methanesulfonic acid 4-{[2'-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carbonyl]-amino}-2-(4-methyl-piperazin-1-yl)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: B(O-i-Pr)3; n-BuLi / -78 - 20 °C

2: 72 percent / Na₂CO₃; Pd(PPh₃)4 / dimethylformamide; H₂O / 24 h / Heating

3: 85 percent / AlCl₃; EtSH / CH₂Cl₂ / 20 °C

4: 86 percent / Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; aluminium trichloride; Triisopropyl borate; sodium carbonate; triethylamine; ethanethiol; In dichloromethane; water; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: demethylation / 4: mesylation;
DOI:10.1021/jm990397l

Reference yield:

: 148547-21-1
[4-({[4-(methyloxy)-3-(4-methyl-1-piperazinyl)phenyl]amino}carbonyl)phenyl]boronic acid

: 256227-78-8
methanesulfonic acid 4-{[2'-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carbonyl]-amino}-2-(4-methyl-piperazin-1-yl)-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Na₂CO₃; Pd(PPh₃)4 / dimethylformamide; H₂O / 24 h / Heating

2: 85 percent / AlCl₃; EtSH / CH₂Cl₂ / 20 °C

3: 86 percent / Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; sodium carbonate; triethylamine; ethanethiol; In dichloromethane; water; N,N-dimethyl-formamide; 1: Substitution / 2: demethylation / 3: mesylation;
DOI:10.1021/jm990397l