tert-butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate
• CAS No.: 333986-61-1
• Molecular Formula: C16H23N3O4
• Molecular Weight: 321.376
• Hs Code.: 2933399090
• Mol file: 333986-61-1.mol

Synonyms:tert-butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate;1-BOC-4-[(4-NITROPHENYL)AMINO]-PIPERIDINE;tert-Butyl 4-((4-nitrophenyl)aMino)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate

Chemical Property:

• Melting Point: 188-189°
• PSA: 87.39000
• LogP: 3.94030

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate

There total 3 articles about tert-butyl 4-(4-nitroanilino)tetrahydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 4-nitro-aniline (100-01-6,104810-17-5) → 1-piperidinecarboxylic acid, 4-(4-nitrophenylamino)-1,1-dimethylethyl ester (333986-61-1)

Guidance literature:

With phenylsilane; dibutyltin chloride; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/ol015948s

Reference yield: 28.0%

→ 1-piperidinecarboxylic acid, 4-(4-nitrophenylamino)-1,1-dimethylethyl ester (333986-61-1)

Guidance literature:

Reference yield:

4-Amino-piperazine-1-carboxylic acid tert-butyl ester (118753-66-5) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-piperidinecarboxylic acid, 4-(4-nitrophenylamino)-1,1-dimethylethyl ester (333986-61-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; water;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

4-nitro-aniline

4-Amino-piperazine-1-carboxylic acid tert-butyl ester

4-Fluoronitrobenzene

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