3-Pyridinecarbonitrile,2-ethoxy-4-(methoxymethyl)-6-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonitrile,2-ethoxy-4-(methoxymethyl)-6-methyl-(9CI)
• CAS No.: 340691-07-8
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.244
• Mol file: 340691-07-8.mol

Synonyms:3-Pyridinecarbonitrile,2-ethoxy-4-(methoxymethyl)-6-methyl-(9CI)

Chemical Property of 3-Pyridinecarbonitrile,2-ethoxy-4-(methoxymethyl)-6-methyl-(9CI)

Chemical Property:

• Melting Point: 57 - 59 °C
• PSA: 55.14000
• LogP: 1.80678

Purity/Quality:

2-ETHOXY-4-(METHOXYMETHYL)-6-METHYL-3-PYRIDINECARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinecarbonitrile,2-ethoxy-4-(methoxymethyl)-6-methyl-(9CI)

There total 2 articles about 3-Pyridinecarbonitrile,2-ethoxy-4-(methoxymethyl)-6-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine (18872-63-4) + ethanol (64-17-5) → 2-Ethoxy-4-methoxymethyl-6-methyl-nicotinonitrile (340691-07-8)

Guidance literature:

With sodium; for 1h; Heating;

Reference yield:

6-methyl-4-[(methyloxy)methyl]-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (6339-38-4) → 2-Ethoxy-4-methoxymethyl-6-methyl-nicotinonitrile (340691-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 1.) POCl₃, 2.) PCl₅ / 1.) reflux, 4.5 h, 2.) reflux, 6 h

2: 60.7 percent / Na / 1 h / Heating

With phosphorus pentachloride; sodium; trichlorophosphate;

Reference yield: 65.0%

(2-aminophenyl)diphenylmethanol (52744-72-6) + 2-Ethoxy-4-methoxymethyl-6-methyl-nicotinonitrile (340691-07-8) → 2-(2-ethoxy-4-methoxymethyl-6-methyl-pyridin-3-yl)-4,4-diphenyl-3,4-dihydro-quinazoline; compound with perchloric acid

Guidance literature:

With perchloric acid; In nitromethane; Heating;

DOI:10.1007/s10593-005-0277-2

upstream raw materials:

6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine

ethanol

6-methyl-4-[(methyloxy)methyl]-2-oxo-1,2-dihydro-3-pyridinecarbonitrile