2-chloro-4-(methoxymethyl)-6-methylnicotinonitrile

Base Information

• Chemical Name: 2-chloro-4-(methoxymethyl)-6-methylnicotinonitrile
• CAS No.: 18872-63-4
• Molecular Formula: C9H9ClN2O
• Molecular Weight: 196.63400
• Mol file: 18872-63-4.mol

Synonyms:2-CHLORO-4-(METHOXYMETHYL)-6-METHYLNICOTINONITRILE;2-chloro-4-methoxymethyl-6-methyl-nicotinonitrile;2-chloro-4-methoxymethyl-6-methylnicotinonitrile;2-Chloro-3-cyano-4-methoxymethyl-6-methylpyridine;2-Chlor-4-methoxymethyl-6-methyl-nicotinonitril;6-methyl-4-methoxymethyl-2-chloro-3-cyanopyridine;6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine;

Chemical Property of 2-chloro-4-(methoxymethyl)-6-methylnicotinonitrile

Chemical Property:

• PSA: 45.91000
• LogP: 2.06148

Purity/Quality:

2-CHLORO-4-(METHOXYMETHYL)-6-METHYLNICOTINONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-4-(methoxymethyl)-6-methylnicotinonitrile

There total 4 articles about 2-chloro-4-(methoxymethyl)-6-methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methyl-4-[(methyloxy)methyl]-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (6339-38-4) → 6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine (18872-63-4)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; 1.) reflux, 4.5 h, 2.) reflux, 6 h;

Reference yield:

2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile (6339-38-4) → 6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine (18872-63-4)

Guidance literature:

With phosphorus pentachloride; chlorobenzene;

DOI:10.1021/ja01136a023

Reference yield:

1-methoxypentane-2,4-dione (6290-50-2) → 6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine (18872-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; piperidine

2: chlorobenzene; PCl₅

With piperidine; ethanol; phosphorus pentachloride; chlorobenzene;

DOI:10.1021/ja01136a023

upstream raw materials:

2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile

6-methyl-4-[(methyloxy)methyl]-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

1-methoxypentane-2,4-dione

Downstream raw materials:

1-(4,6-dimethylpyridin-3-yl)methanamine

3-amino-4-methoxymethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine

C₁₅H₁₆FN₃O₂

C₂₂H₁₉F₂N₃O₂